Ipsilateral and contralateral cerebro-cerebellar white matter connections: A diffusion tensor imaging study in healthy adults

: The cerebellum has a pivotal role in regulating human behavior; yet whether this function is mediated only through contralateral cerebro-cerebellar pathways is under-investigated. Thus, we examined feed-backward and feed-forward ipsilateral and contralateral cerebro-cerebellar connections using a...

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Vydané v:Journal of neuroradiology Ročník 46; číslo 1; s. 52 - 60
Hlavní autori: Karavasilis, Efstratios, Christidi, Foteini, Velonakis, Georgios, Giavri, Zoi, Kelekis, Nikolaos L., Efstathopoulos, Efstathios P., Evdokimidis, Ioannis, Dellatolas, Georges
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: France Elsevier Masson SAS 01.02.2019
Predmet:
Adult
Algorithms
Cerebellum
Cerebellum - anatomy & histology
Cerebro-cerebellar
Diffusion tensor imaging
Diffusion Tensor Imaging - methods
Female
Healthy Volunteers
Humans
Male
Middle Aged
Neural Pathways - anatomy & histology
Phantom
Phantoms, Imaging
Reference Values
Tractography
White matter
White Matter - anatomy & histology
Cerebellum
Phantom
Cerebro-cerebellar
White matter
Tractography
Diffusion tensor imaging
ISSN:0150-9861
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Shrnutí:: The cerebellum has a pivotal role in regulating human behavior; yet whether this function is mediated only through contralateral cerebro-cerebellar pathways is under-investigated. Thus, we examined feed-backward and feed-forward ipsilateral and contralateral cerebro-cerebellar connections using a detereministic diffusion tensor imaging (DTI) algorithm, the robustness of which was also estimated using phantom DTI data. : Fifty-one healthy controls (22–60 years old; 15 males/36 females) were scanned in a 3T MRI scanner with a 30-direction DTI sequence. Multiple region-of-interest (ROI) method was applied for the reconstruction of the ipsilateral and contralateral (based on cerebellar seed ROI) fronto-ponto-cerebellar (FPC), parieto-ponto-cerebellar (PPC), temporo-ponto-cerebellar (TPC), occipito-ponto-cerebellar (OPC) and dentate-rubro-thalamo-cortical (DRTC) tract bilaterally using the Brainance DTI Suite. A realistic diffusion MR phantom was used to evaluate the fiber tracking methodology for 16 fibers containing crossing, kissing, splitting and bending configurations. Both contralateral and ipsilateral FPC, PPC, OPC and ipsilateral DRTC tracts were successfully reconstructed; the contralateral DRTC tract was not reconstructed in all subjects. Also, the TPC tract was not reproduced in several subjects mostly regarding the contralateral connection. Descriptive DTI measures (number of fibers, fractional anisotropy, radial and axial diffusivity) are presented for each tract. Regarding phantom data, Brainance DTI Suite returned a dataset of 16 fibers that almost perfectly matched the 16 ground truth fibers. We identified ipsilateral and contralateral connections using a clinically applicable DTI sequence, a robust deterministic algorithm and an unbiased methodology, which can be applied in daily practice in different brain pathologies.
Bibliografia:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:0150-9861
DOI:10.1016/j.neurad.2018.07.004