Macrophage Migration Inhibitory Factor: A Novel Inhibitor of Apoptosis Signal-Regulating Kinase 1–p38–Xanthine Oxidoreductase–Dependent Cigarette Smoke–Induced Apoptosis

Cigarette smoke (CS) exposure is the leading cause of emphysema. CS mediates pathologic emphysematous remodeling of the lung via apoptosis of lung parenchymal cells resulting in enlargement of the airspaces, loss of the capillary bed, and diminished surface area for gas exchange. Macrophage migratio...

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Bibliographic Details
Published in:	American journal of respiratory cell and molecular biology Vol. 54; no. 4; pp. 504 - 514
Main Authors:	Fallica, Jonathan, Varela, Lidenys, Johnston, Laura, Kim, Bo, Serebreni, Leonid, Wang, Lan, Damarla, Mahendra, Kolb, Todd M., Hassoun, Paul M., Damico, Rachel
Format:	Journal Article
Language:	English
Published:	United States American Thoracic Society 01.04.2016
Subjects:	Animals Apoptosis Cells, Cultured Chronic obstructive pulmonary disease Cytotoxicity Deoxyribonucleic acid DNA Emphysema Enzyme Activation Enzymes Human subjects Humans Kinases Lungs Macrophage Migration-Inhibitory Factors - genetics Macrophage Migration-Inhibitory Factors - physiology MAP Kinase Kinase Kinase 5 - metabolism Mice Mice, Inbred C57BL Nicotiana Original Research Oxidative stress p38 Mitogen-Activated Protein Kinases - metabolism Phosphorylation Proteins Rats Reactive Oxygen Species - metabolism Rodents Smoke Xanthine Dehydrogenase - metabolism apoptosis cigarette migration inhibitory factor apoptosis signal–regulating kinase 1 xanthine oxidase
ISSN:	1044-1549, 1535-4989, 1535-4989
Online Access:	Get full text
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