Peripheral Artery Disease: Past, Present, and Future
Peripheral artery disease is a prevalent but underdiagnosed manifestation of atherosclerosis. There is insufficient awareness of its clinical manifestations, including intermittent claudication and critical limb ischemia and of its risk of adverse cardiovascular and limb outcomes. In addition, our i...
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| Vydáno v: | The American journal of medicine Ročník 132; číslo 10; s. 1133 |
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| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
01.10.2019
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| ISSN: | 1555-7162, 1555-7162 |
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| Abstract | Peripheral artery disease is a prevalent but underdiagnosed manifestation of atherosclerosis. There is insufficient awareness of its clinical manifestations, including intermittent claudication and critical limb ischemia and of its risk of adverse cardiovascular and limb outcomes. In addition, our inadequate knowledge of its pathophysiology has also limited the development of effective treatments, particularly in the presence of critical limb ischemia. This review aims to highlight essential elements of the epidemiology and pathophysiology of peripheral artery disease, bring attention to the often-atypical manifestations of occlusive arterial disease of the lower extremity, increase awareness of critical limb ischemia, briefly describe the diagnostic role of the ankle brachial index, and go over the contemporary management of peripheral artery disease. An emphasis is placed on evidence-based medical treatments to improve symptoms and quality of life and to reduce the risk of cardiovascular and limb events in these patients, including supervised exercise training, smoking cessation, antagonism of the renin-angiotensin system, lipid-lowering, antiplatelet, and antithrombotic therapies. |
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| AbstractList | Peripheral artery disease is a prevalent but underdiagnosed manifestation of atherosclerosis. There is insufficient awareness of its clinical manifestations, including intermittent claudication and critical limb ischemia and of its risk of adverse cardiovascular and limb outcomes. In addition, our inadequate knowledge of its pathophysiology has also limited the development of effective treatments, particularly in the presence of critical limb ischemia. This review aims to highlight essential elements of the epidemiology and pathophysiology of peripheral artery disease, bring attention to the often-atypical manifestations of occlusive arterial disease of the lower extremity, increase awareness of critical limb ischemia, briefly describe the diagnostic role of the ankle brachial index, and go over the contemporary management of peripheral artery disease. An emphasis is placed on evidence-based medical treatments to improve symptoms and quality of life and to reduce the risk of cardiovascular and limb events in these patients, including supervised exercise training, smoking cessation, antagonism of the renin-angiotensin system, lipid-lowering, antiplatelet, and antithrombotic therapies.Peripheral artery disease is a prevalent but underdiagnosed manifestation of atherosclerosis. There is insufficient awareness of its clinical manifestations, including intermittent claudication and critical limb ischemia and of its risk of adverse cardiovascular and limb outcomes. In addition, our inadequate knowledge of its pathophysiology has also limited the development of effective treatments, particularly in the presence of critical limb ischemia. This review aims to highlight essential elements of the epidemiology and pathophysiology of peripheral artery disease, bring attention to the often-atypical manifestations of occlusive arterial disease of the lower extremity, increase awareness of critical limb ischemia, briefly describe the diagnostic role of the ankle brachial index, and go over the contemporary management of peripheral artery disease. An emphasis is placed on evidence-based medical treatments to improve symptoms and quality of life and to reduce the risk of cardiovascular and limb events in these patients, including supervised exercise training, smoking cessation, antagonism of the renin-angiotensin system, lipid-lowering, antiplatelet, and antithrombotic therapies. Peripheral artery disease is a prevalent but underdiagnosed manifestation of atherosclerosis. There is insufficient awareness of its clinical manifestations, including intermittent claudication and critical limb ischemia and of its risk of adverse cardiovascular and limb outcomes. In addition, our inadequate knowledge of its pathophysiology has also limited the development of effective treatments, particularly in the presence of critical limb ischemia. This review aims to highlight essential elements of the epidemiology and pathophysiology of peripheral artery disease, bring attention to the often-atypical manifestations of occlusive arterial disease of the lower extremity, increase awareness of critical limb ischemia, briefly describe the diagnostic role of the ankle brachial index, and go over the contemporary management of peripheral artery disease. An emphasis is placed on evidence-based medical treatments to improve symptoms and quality of life and to reduce the risk of cardiovascular and limb events in these patients, including supervised exercise training, smoking cessation, antagonism of the renin-angiotensin system, lipid-lowering, antiplatelet, and antithrombotic therapies. |
| Author | Gerhard-Herman, Marie Goldhaber, Samuel Z Campia, Umberto Piazza, Gregory |
| Author_xml | – sequence: 1 givenname: Umberto surname: Campia fullname: Campia, Umberto email: ucampia@bwh.harvard.edu organization: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston. Electronic address: ucampia@bwh.harvard.edu – sequence: 2 givenname: Marie surname: Gerhard-Herman fullname: Gerhard-Herman, Marie organization: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston – sequence: 3 givenname: Gregory surname: Piazza fullname: Piazza, Gregory organization: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston – sequence: 4 givenname: Samuel Z surname: Goldhaber fullname: Goldhaber, Samuel Z organization: Department of Medicine, Cardiovascular Division, Brigham and Women's Hospital, Boston, Mass; Harvard Medical School, Boston |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/31150643$$D View this record in MEDLINE/PubMed |
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| Keywords | Peripheral artery disease Critical limb ischemia Cardiovascular risk Intermittent claudication |
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| Title | Peripheral Artery Disease: Past, Present, and Future |
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