Stimulation of lymphangiogenesis via VEGFR-3 inhibits chronic skin inflammation

The role of lymphangiogenesis in inflammation has remained unclear. To investigate the role of lymphatic versus blood vasculature in chronic skin inflammation, we inhibited vascular endothelial growth factor (VEGF) receptor (VEGFR) signaling by function-blocking antibodies in the established keratin...

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Veröffentlicht in:	The Journal of experimental medicine Jg. 207; H. 10; S. 2255
Hauptverfasser:	Huggenberger, Reto, Ullmann, Stefan, Proulx, Steven T, Pytowski, Bronislaw, Alitalo, Kari, Detmar, Michael
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 27.09.2010
Schlagworte:	Animals Antibodies, Blocking - immunology CD8-Positive T-Lymphocytes - immunology Chronic Disease Dermatitis - genetics Dermatitis - immunology Dermatitis - metabolism Dermatitis - therapy Keratin-14 - genetics Lymphangiogenesis Mice Mice, Transgenic Skin - blood supply Skin - immunology Skin - metabolism Vascular Endothelial Growth Factor A - genetics Vascular Endothelial Growth Factor D - administration & dosage Vascular Endothelial Growth Factor D - immunology Vascular Endothelial Growth Factor Receptor-2 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-2 - immunology Vascular Endothelial Growth Factor Receptor-3 - antagonists & inhibitors Vascular Endothelial Growth Factor Receptor-3 - immunology Vascular Endothelial Growth Factor Receptor-3 - metabolism
ISSN:	1540-9538, 1540-9538
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