Targeting Asparagine and Serine Metabolism in Germinal Centre-Derived B Cells Non-Hodgkin Lymphomas (B-NHL)

BL and DLBCL are subtypes of B-cell lymphomas that arise from germinal centre B lymphocytes. Differentiation between BL and DLBCL is critical and can be challenging, as these two types of cancer share the same morphological, immunophenotypic, and genetic characteristics. In this study, we have exami...

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Vydáno v:Cells (Basel, Switzerland) Ročník 10; číslo 10; s. 2589
Hlavní autoři: Eraslan, Zuhal, Papatzikas, Grigorios, Cazier, Jean-Baptiste, Khanim, Farhat L., Günther, Ulrich L.
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 29.09.2021
MDPI
Témata:
Amino acids
Antitumor agents
Asparaginase
Asparagine
Asparagine - metabolism
B-cell lymphoma
Biosynthesis
Cancer therapies
Cell culture
Gene expression
Germinal centers
Glucose
Humans
Lymphocytes B
Lymphoma
Lymphoma, Non-Hodgkin - metabolism
Metabolism
Metabolites
metabolomics
Metabolomics - methods
non-Hodgkin lymphomas
Physical characteristics
Serine
Serine - metabolism
Software
Tumors
United Kingdom > UK
France
United States > US
metabolomics
non-Hodgkin lymphomas
metabolism
ISSN:2073-4409, 2073-4409
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Abstract BL and DLBCL are subtypes of B-cell lymphomas that arise from germinal centre B lymphocytes. Differentiation between BL and DLBCL is critical and can be challenging, as these two types of cancer share the same morphological, immunophenotypic, and genetic characteristics. In this study, we have examined metabolism in BL and DLBCL lymphomas and found distinctive differences in serine metabolism. We show that BL cells consume significantly more extracellular asparagine than DLBCL cells. Using a tracer-based approach, we find that asparagine regulates the serine uptake and serine synthesis in BL and DLBCL cells. Calculation of Differentially Expressed Genes (DEGs) from RNAseq datasets of BL and DLBCL patients show that BL cancers express the genes involved in serine synthesis at a higher level than DLBCL. Remarkably, combined use of an inhibitor of serine biosynthesis pathway and an anticancer drug asparaginase increases the sensitivity of BL cells to extracellular asparagine deprivation without inducing a change in the sensitivity of DLBCL cells to asparaginase. In summary, our study unravels metabolic differences between BL and DLBCL with diagnostic potential which may also open new avenues for treatment.
AbstractList BL and DLBCL are subtypes of B-cell lymphomas that arise from germinal centre B lymphocytes. Differentiation between BL and DLBCL is critical and can be challenging, as these two types of cancer share the same morphological, immunophenotypic, and genetic characteristics. In this study, we have examined metabolism in BL and DLBCL lymphomas and found distinctive differences in serine metabolism. We show that BL cells consume significantly more extracellular asparagine than DLBCL cells. Using a tracer-based approach, we find that asparagine regulates the serine uptake and serine synthesis in BL and DLBCL cells. Calculation of Differentially Expressed Genes (DEGs) from RNAseq datasets of BL and DLBCL patients show that BL cancers express the genes involved in serine synthesis at a higher level than DLBCL. Remarkably, combined use of an inhibitor of serine biosynthesis pathway and an anticancer drug asparaginase increases the sensitivity of BL cells to extracellular asparagine deprivation without inducing a change in the sensitivity of DLBCL cells to asparaginase. In summary, our study unravels metabolic differences between BL and DLBCL with diagnostic potential which may also open new avenues for treatment.
BL and DLBCL are subtypes of B-cell lymphomas that arise from germinal centre B lymphocytes. Differentiation between BL and DLBCL is critical and can be challenging, as these two types of cancer share the same morphological, immunophenotypic, and genetic characteristics. In this study, we have examined metabolism in BL and DLBCL lymphomas and found distinctive differences in serine metabolism. We show that BL cells consume significantly more extracellular asparagine than DLBCL cells. Using a tracer-based approach, we find that asparagine regulates the serine uptake and serine synthesis in BL and DLBCL cells. Calculation of Differentially Expressed Genes (DEGs) from RNAseq datasets of BL and DLBCL patients show that BL cancers express the genes involved in serine synthesis at a higher level than DLBCL. Remarkably, combined use of an inhibitor of serine biosynthesis pathway and an anticancer drug asparaginase increases the sensitivity of BL cells to extracellular asparagine deprivation without inducing a change in the sensitivity of DLBCL cells to asparaginase. In summary, our study unravels metabolic differences between BL and DLBCL with diagnostic potential which may also open new avenues for treatment.BL and DLBCL are subtypes of B-cell lymphomas that arise from germinal centre B lymphocytes. Differentiation between BL and DLBCL is critical and can be challenging, as these two types of cancer share the same morphological, immunophenotypic, and genetic characteristics. In this study, we have examined metabolism in BL and DLBCL lymphomas and found distinctive differences in serine metabolism. We show that BL cells consume significantly more extracellular asparagine than DLBCL cells. Using a tracer-based approach, we find that asparagine regulates the serine uptake and serine synthesis in BL and DLBCL cells. Calculation of Differentially Expressed Genes (DEGs) from RNAseq datasets of BL and DLBCL patients show that BL cancers express the genes involved in serine synthesis at a higher level than DLBCL. Remarkably, combined use of an inhibitor of serine biosynthesis pathway and an anticancer drug asparaginase increases the sensitivity of BL cells to extracellular asparagine deprivation without inducing a change in the sensitivity of DLBCL cells to asparaginase. In summary, our study unravels metabolic differences between BL and DLBCL with diagnostic potential which may also open new avenues for treatment.
Author Cazier, Jean-Baptiste
Khanim, Farhat L.
Papatzikas, Grigorios
Eraslan, Zuhal
Günther, Ulrich L.
AuthorAffiliation 2 Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK; gr.papatzikas@gmail.com (G.P.); J.Cazier@bham.ac.uk (J.-B.C.)
4 Institute for Chemistry and Metabolomics, University of Lübeck, 23562 Lübeck, Germany
1 Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK; eraslanzuhal1@gmail.com (Z.E.); f.l.khanim@bham.ac.uk (F.L.K.)
3 Centre for Computational Biology, University of Birmingham, Birmingham B15 2TT, UK
AuthorAffiliation_xml – name: 4 Institute for Chemistry and Metabolomics, University of Lübeck, 23562 Lübeck, Germany
– name: 1 Institute of Clinical Sciences, University of Birmingham, Birmingham B15 2TT, UK; eraslanzuhal1@gmail.com (Z.E.); f.l.khanim@bham.ac.uk (F.L.K.)
– name: 2 Institute of Cancer and Genomic Sciences, University of Birmingham, Birmingham B15 2TT, UK; gr.papatzikas@gmail.com (G.P.); J.Cazier@bham.ac.uk (J.-B.C.)
– name: 3 Centre for Computational Biology, University of Birmingham, Birmingham B15 2TT, UK
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  orcidid: 0000-0003-1108-824X
  surname: Eraslan
  fullname: Eraslan, Zuhal
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  surname: Papatzikas
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  fullname: Khanim, Farhat L.
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  givenname: Ulrich L.
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BackLink https://www.ncbi.nlm.nih.gov/pubmed/34685569$$D View this record in MEDLINE/PubMed
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Keywords metabolomics
non-Hodgkin lymphomas
metabolism
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F.L.K., J.-B.C. and U.L.G. jointly supervised this work and made equal contributions.
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  publication-title: Sci. Rep.
  doi: 10.1038/s41598-018-37525-3
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Snippet BL and DLBCL are subtypes of B-cell lymphomas that arise from germinal centre B lymphocytes. Differentiation between BL and DLBCL is critical and can be...
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SubjectTerms Amino acids
Antitumor agents
Asparaginase
Asparagine
Asparagine - metabolism
B-cell lymphoma
Biosynthesis
Cancer therapies
Cell culture
Gene expression
Germinal centers
Glucose
Humans
Lymphocytes B
Lymphoma
Lymphoma, Non-Hodgkin - metabolism
Metabolism
Metabolites
metabolomics
Metabolomics - methods
non-Hodgkin lymphomas
Physical characteristics
Serine
Serine - metabolism
Software
Tumors
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Title Targeting Asparagine and Serine Metabolism in Germinal Centre-Derived B Cells Non-Hodgkin Lymphomas (B-NHL)
URI https://www.ncbi.nlm.nih.gov/pubmed/34685569
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