Circulating microRNAs as potential markers of human drug‐induced liver injury

New biomarkers of liver injury are required in the clinic and in preclinical pharmaceutical evaluation. Previous studies demonstrate that two liver‐enriched microRNAs (miR‐122 and miR‐192) are promising biomarkers of acetaminophen‐induced acute liver injury (APAP‐ALI) in mice. We have examined these...

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Vydáno v:	Hepatology (Baltimore, Md.) Ročník 54; číslo 5; s. 1767 - 1776
Hlavní autoři:	Starkey Lewis, Philip J., Dear, James, Platt, Vivien, Simpson, Kenneth J., Craig, Darren G.N., Antoine, Daniel J., French, Neil S., Dhaun, Neeraj, Webb, David J., Costello, Eithne M., Neoptolemos, John P., Moggs, Jonathan, Goldring, Chris E., Park, B. Kevin
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Hoboken Wiley Subscription Services, Inc., A Wiley Company 01.11.2011 Wiley Wolters Kluwer Health, Inc
Témata:	Acetaminophen - poisoning Acute Disease Adolescent Adult Aged Alanine Transaminase - blood Analgesics, Non-Narcotic - poisoning Biological and medical sciences Biomarkers Biomarkers - blood Chemical and Drug Induced Liver Injury - blood Chemical and Drug Induced Liver Injury - diagnosis Chemical and Drug Induced Liver Injury - surgery Diagnostic Techniques, Digestive System Drug toxicity and drugs side effects treatment Female Gastroenterology. Liver. Pancreas. Abdomen Hepatology Humans Liver Liver Transplantation Liver. Biliary tract. Portal circulation. Exocrine pancreas Male Medical sciences MicroRNAs MicroRNAs - blood Middle Aged Pharmacology. Drug treatments Prospective Studies Toxicity: digestive system Young Adult Human Digestive diseases Hepatic disease Hepatotoxicity Gastroenterology
ISSN:	0270-9139, 1527-3350, 1527-3350
On-line přístup:	Získat plný text
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