Zebrafish as model organisms for studying drug‐induced liver injury

Drug‐induced liver injury (DILI) is a major challenge in clinical medicine and drug development. New models are needed for predicting which potential therapeutic compounds will cause DILI in humans, and new markers and mediators of DILI still need to be identified. This review highlights the strengt...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 78; no. 6; pp. 1217 - 1227
Main Authors:	Vliegenthart, A. D. Bastiaan, Tucker, Carl S., Del Pozo, Jorge, Dear, James W.
Format:	Journal Article
Language:	English
Published:	England BlackWell Publishing Ltd 01.12.2014
Subjects:	acetaminophen Animals Biomarkers - blood Chemical and Drug Induced Liver Injury - metabolism Chemical and Drug Induced Liver Injury - pathology Cytochrome P-450 Enzyme System - genetics Disease Models, Animal Drug Discovery drug‐induced liver injury hepatotoxicity Humans Liver - anatomy & histology Liver - pathology liver toxicity Mice paracetamol Phenotype Reviews zebrafish Zebrafish - anatomy & histology Zebrafish - immunology Zebrafish - metabolism drug-induced liver injury acetaminophen paracetamol zebrafish liver toxicity hepatotoxicity
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
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