Tutorial on Monoclonal Antibody Pharmacokinetics and Its Considerations in Early Development
The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in the context of drug development. Topics covered include an overview of antibody development, PK characteristics, and the application of antibody PK/pharmacodynamics (PD) in research and development decision‐...
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| Veröffentlicht in: | Clinical and translational science Jg. 11; H. 6; S. 540 - 552 |
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| Hauptverfasser: | , |
| Format: | Journal Article |
| Sprache: | Englisch |
| Veröffentlicht: |
United States
John Wiley and Sons Inc
01.11.2018
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| Schlagworte: | |
| ISSN: | 1752-8054, 1752-8062, 1752-8062 |
| Online-Zugang: | Volltext |
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| Zusammenfassung: | The tutorial introduces the readers to the fundamentals of antibody pharmacokinetics (PK) in the context of drug development. Topics covered include an overview of antibody development, PK characteristics, and the application of antibody PK/pharmacodynamics (PD) in research and development decision‐making. We also discuss the general considerations for planning a nonclinical PK program and describe the types of PK studies that should be performed during early development of monoclonal antibodies. |
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| Bibliographie: | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 23 |
| ISSN: | 1752-8054 1752-8062 1752-8062 |
| DOI: | 10.1111/cts.12567 |