The nitric oxide pathway and possible therapeutic options in pre‐eclampsia

Pre‐eclampsia is a serious multisystem disorder with diverse clinical manifestations. Although not causal, endothelial dysfunction and reduced nitric oxide bioavailability are likely to play an important role in the maternal and fetal pathophysiology of this condition. Lack of treatment modalities t...

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Bibliographic Details
Published in:	British journal of clinical pharmacology Vol. 78; no. 2; pp. 244 - 257
Main Authors:	Johal, Tamanrit, Lees, Christoph C., Everett, Thomas R., Wilkinson, Ian B.
Format:	Journal Article
Language:	English
Published:	England Blackwell Science Inc 01.08.2014
Subjects:	Aldehyde Oxidoreductases - antagonists & inhibitors Clinical Trials as Topic endothelial dysfunction Endothelium, Vascular - drug effects Endothelium, Vascular - metabolism Female Humans Isosorbide Dinitrate - administration & dosage Isosorbide Dinitrate - therapeutic use l‐arginine Nitric Oxide - metabolism Nitric Oxide Donors - administration & dosage Nitric Oxide Donors - therapeutic use Nitroglycerin - administration & dosage Nitroglycerin - therapeutic use organic nitrates Phosphodiesterase Inhibitors - administration & dosage Phosphodiesterase Inhibitors - therapeutic use Piperazines - administration & dosage Piperazines - therapeutic use Pre-Eclampsia - enzymology Pre-Eclampsia - etiology Pre-Eclampsia - metabolism Pre-Eclampsia - prevention & control Pregnancy pre‐eclampsia Purines - administration & dosage Purines - therapeutic use Reviews S-Nitrosothiols - administration & dosage S-Nitrosothiols - therapeutic use sildenafil Sildenafil Citrate Sulfonamides - administration & dosage Sulfonamides - therapeutic use S‐nitrosoglutathione pre-eclampsia S-nitrosoglutathione l-arginine organic nitrates endothelial dysfunction sildenafil
ISSN:	0306-5251, 1365-2125, 1365-2125
Online Access:	Get full text
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