Brief Report: Impact of the COVID-19 Pandemic on Virological Suppression in People Living With HIV Attending a Large Italian HIV Clinic

We assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on HIV suppression rates in people living with HIV (PLWH) attending a large Italian HIV clinic. The HIV outpatient clinic of the Infectious Diseases Department of Luigi Sacco Hospital, Milan, Italy, which serves more than 500...

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Veröffentlicht in:Journal of acquired immune deficiency syndromes (1999) Jg. 88; H. 3; S. 299
Hauptverfasser: Giacomelli, Andrea, Bonazzetti, Cecilia, Conti, Federico, Pezzati, Laura, Oreni, Letizia, Micheli, Valeria, Mancon, Alessandro, Vimercati, Stefania, Albrecht, Maria, Passerini, Matteo, Cossu, Maria Vittoria, Capetti, Amedeo Ferdinando, Meraviglia, Paola, Antinori, Spinello, Rizzardini, Giuliano, Galli, Massimo, Ridolfo, Anna Lisa
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 01.11.2021
Schlagworte:
Ambulatory Care Facilities
Anti-HIV Agents - administration & dosage
Anti-HIV Agents - therapeutic use
COVID-19 - complications
COVID-19 - epidemiology
Delivery of Health Care - methods
HIV Infections - complications
HIV Infections - drug therapy
HIV Infections - epidemiology
HIV-1
Humans
Italy - epidemiology
RNA, Viral - blood
SARS-CoV-2
Viral Load - drug effects
Italy
ISSN:1944-7884, 1944-7884
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Zusammenfassung:We assessed the impact of the coronavirus disease 2019 (COVID-19) pandemic on HIV suppression rates in people living with HIV (PLWH) attending a large Italian HIV clinic. The HIV outpatient clinic of the Infectious Diseases Department of Luigi Sacco Hospital, Milan, Italy, which serves more than 5000 PLWH per year. A before and after quasi-experimental study design was used to make a retrospective assessment of the monthly trend of HIV-RNA determinations of ≥50 among the PLWH attending our clinic, with "before" being the period from January 1, 2016 to February 20, 2020, and "after" being the period from February 21, 2020 to December 31, 2020 (the COVID-19 period). Interrupted time series analysis was used to evaluate any changes in the trend. During the study period, 70,349 HIV-RNA viral load determinations were made, and the percentage of HIV-RNA viral load determinations of <50 copies/mL increased from 88.4% in 2016 to 93.2% in 2020 (P < 0.0001). There was a significant monthly trend toward a decrease in the number of HIV-RNA determinations of ≥50 copies/mL before the pandemic (β -0.084; standard error 0.015; P < 0.001), and this did not significantly change after it started (β -0.039, standard error 0.161; P = 0.811). A high prevalence of viral suppression was maintained among the PLWH referring to our clinic, despite the structural barriers raised by the COVID-19 pandemic. The use of simplified methods of delivering care (such as teleconsultations and multiple antiretroviral treatment prescriptions) may have contributed to preserving this continuum.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 23
ISSN:1944-7884
1944-7884
DOI:10.1097/QAI.0000000000002754