Sustainable Synthesis of Diverse Privileged Heterocycles by Palladium-Catalyzed Aerobic Oxidative Isocyanide Insertion

O2 in, H2O out: Various diamines and related bisnucleophiles readily undergo oxidative isocyanide insertion with Pd(OAc)2 (1 mol %) as the catalyst and O2 as the terminal oxidant to give a diverse array of medicinally relevant N heterocycles. The utility of this highly sustainable method is demonstr...

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Bibliographic Details
Published in:	Angewandte Chemie International Edition Vol. 51; no. 52; pp. 13058 - 13061
Main Authors:	Vlaar, Tjøstil, Cioc, Razvan C., Mampuys, Pieter, Maes, Bert U. W., Orru, Romano V. A., Ruijter, Eelco
Format:	Journal Article
Language:	English
Published:	Weinheim WILEY-VCH Verlag 21.12.2012 WILEY‐VCH Verlag Wiley Subscription Services, Inc
Edition:	International ed. in English
Subjects:	Antihistamines Arrays Astemizole - chemical synthesis Astemizole - chemistry Benzimidazoles - chemical synthesis Benzimidazoles - chemistry Catalysis Cyanides - chemistry Diamines Diamines - chemistry guanidines Guanidines - chemistry heterocycles Heterocyclic Compounds - chemical synthesis Heterocyclic Compounds - chemistry homogeneous catalysis Insertion isocyanides Oxidants oxidation Oxidation-Reduction Oxidizing agents Palladium Palladium - chemistry Piperidines - chemical synthesis Piperidines - chemistry Synthesis Terminals Utilities
ISSN:	1433-7851, 1521-3773, 1521-3773
Online Access:	Get full text
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