Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression

Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53. We generated genetically engineered inducible mice and showed that H3.3 K27M enhanced neural stem cell self-renewal while preservin...

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Veröffentlicht in:	Cancer cell Jg. 35; H. 1; S. 140
Hauptverfasser:	Larson, Jon D, Kasper, Lawryn H, Paugh, Barbara S, Jin, Hongjian, Wu, Gang, Kwon, Chang-Hyuk, Fan, Yiping, Shaw, Timothy I, Silveira, André B, Qu, Chunxu, Xu, Raymond, Zhu, Xiaoyan, Zhang, Junyuan, Russell, Helen R, Peters, Jennifer L, Finkelstein, David, Xu, Beisi, Lin, Tong, Tinkle, Christopher L, Patay, Zoltan, Onar-Thomas, Arzu, Pounds, Stanley B, McKinnon, Peter J, Ellison, David W, Zhang, Jinghui, Baker, Suzanne J
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 14.01.2019
Schlagworte:	Animals Brain Stem Neoplasms - genetics Cell Self Renewal Cells, Cultured Epigenesis, Genetic Gene Expression Profiling - methods Gene Expression Regulation, Neoplastic Glioma - genetics Histones - genetics Histones - metabolism Humans Mice Mutation Neural Stem Cells - cytology Receptor, Platelet-Derived Growth Factor alpha - genetics Rhombencephalon - pathology Sequence Analysis, RNA - methods Tumor Suppressor Protein p53 - genetics PDGFRA mouse knockin epigenetic histone H3 K27M bivalent oncohistone glioma DIPG H3K27me3
ISSN:	1878-3686, 1878-3686
Online-Zugang:	Weitere Angaben
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