Transcriptomic and cellular decoding of functional brain connectivity changes reveal regional brain vulnerability to pro- and anti-inflammatory therapies

•Inflammation has heterogenous effects on brain function which are poorly understood.•INF-α and anti-TNF therapies produce differential decreases in regional connectivity.•The transcriptomic landscape of the brain explains regional variance in these effects.•INF-α is linked to constitutive expressio...

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Veröffentlicht in:	Brain, behavior, and immunity Jg. 102; S. 312 - 323
Hauptverfasser:	Martins, D., Dipasquale, O., Davies, K., Cooper, E., Tibble, J., Veronese, M., Frigo, M., Williams, S.C.R., Turkheimer, F., Cercignani, M., Harrison, N.A.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	Netherlands Elsevier Inc 01.05.2022 Elsevier
Schlagworte:	Anti-Inflammatory Agents - pharmacology Anti-TNF Brain Depression Global brain connectivity Humans Imaging transcriptomics Immunology Immunotherapy Inflammation Interferon-alpha - adverse effects Interferon-α Life Sciences Neurobiology Neurons and Cognition Pharmaceutical sciences Pharmacology Transcriptome Transcriptomic vulnerability Tumor Necrosis Factor Inhibitors Anti-TNF Depression Interferon-α Transcriptomic vulnerability Global brain connectivity Imaging transcriptomics
ISSN:	0889-1591, 1090-2139, 1090-2139
Online-Zugang:	Volltext
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