Phylogenetic Analysis of Chandipura virus: Insights from a Preliminary Genomic Study

Chandipura virus (CHPV) is an arthropod-borne virus linked to encephalitis in humans, primarily in India. Its evolutionary dynamics and transmission pathways remain poorly understood due to limited genomic data. This study analyzed 23 publicly available CHPV genomes, including isolates from humans,...

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Vydáno v:International journal of molecular sciences Ročník 26; číslo 3; s. 1021
Hlavní autoři: Giovanetti, Marta, Micheli, Valeria, Mancon, Alessandro, Mileto, Davide, Rizzo, Alberto
Médium: Journal Article
Jazyk:angličtina
Vydáno: Switzerland MDPI AG 01.02.2025
MDPI
Témata:
Animals
Communication
Disease
Encephalitis
Epidemics
Evolution
Evolution, Molecular
Fourier transforms
Genetic diversity
Genome, Viral
Genomes
Genomics
Genomics - methods
Hedgehogs - virology
Humans
India
Integrated approach
Phylogenetics
Phylogeny
Psychodidae - virology
Rhabdoviridae Infections - virology
Surveillance
Vesiculovirus - classification
Vesiculovirus - genetics
Vesiculovirus - isolation & purification
Viruses
India
Kenya
Senegal
surveillance
one health
phylogenesis
Chandipura virus
emerging pathogen
ISSN:1422-0067, 1661-6596, 1422-0067
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Shrnutí:Chandipura virus (CHPV) is an arthropod-borne virus linked to encephalitis in humans, primarily in India. Its evolutionary dynamics and transmission pathways remain poorly understood due to limited genomic data. This study analyzed 23 publicly available CHPV genomes, including isolates from humans, sandflies, and a hedgehog, retrieved from GenBank. Phylogenetic analyses were conducted to explore host-specific and geographic evolutionary patterns. Phylogenetic analysis revealed distinct evolutionary lineages. Human-derived genomes collected in India between 2003 and 2024 formed a well-supported monophyletic clade, suggesting a unique evolutionary lineage. In contrast, sandfly-derived genomes exhibited diverse clustering patterns. Notably, Kenyan sandfly isolates from 2016–2017 were phylogenetically closer to human-derived sequences, suggesting possible shared evolutionary pressures. These findings provide preliminary insights into CHPV evolution and emphasize the need for enhanced genomic surveillance in both human and non-human populations. Expanding genomic data is essential to validate these observations and inform public health strategies.
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ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms26031021