Adjuvant and neoadjuvant therapy for biliary tract cancer: a review of clinical trials

Cancer originating in the biliary tract can be classified as bile duct cancer (cholangiocarcinoma), gallbladder cancer, or ampullary cancer. Bile duct cancer is further divided to intrahepatic, perihilar and distal bile duct subtypes according to the anatomical location of the tumor. The biological...

Ausführliche Beschreibung

Gespeichert in:
Bibliographische Detailangaben
Veröffentlicht in:Japanese journal of clinical oncology Jg. 50; H. 12; S. 1353
Hauptverfasser: Nara, Satoshi, Esaki, Minoru, Ban, Daisuke, Takamoto, Takeshi, Shimada, Kazuaki, Ioka, Tatsuya, Okusaka, Takuji, Ishii, Hiroshi, Furuse, Junji
Format: Journal Article
Sprache:Englisch
Veröffentlicht: England 16.12.2020
Schlagworte:
Antineoplastic Combined Chemotherapy Protocols - therapeutic use
Biliary Tract Neoplasms - classification
Biliary Tract Neoplasms - drug therapy
Biliary Tract Neoplasms - pathology
Biliary Tract Neoplasms - surgery
Capecitabine - therapeutic use
Chemotherapy, Adjuvant
Cisplatin - therapeutic use
Clinical Trials as Topic
Deoxycytidine - analogs & derivatives
Deoxycytidine - therapeutic use
Drug Combinations
Humans
Neoadjuvant Therapy
Oxonic Acid - therapeutic use
Tegafur - therapeutic use
biliary tract cancer
carcinoma of the ampulla of Vater
gallbladder cancer
bile duct cancer
cholangiocarcinoma
ISSN:1465-3621, 1465-3621
Online-Zugang:Weitere Angaben
Tags: Tag hinzufügen
Keine Tags, Fügen Sie den ersten Tag hinzu!
Beschreibung
Zusammenfassung:Cancer originating in the biliary tract can be classified as bile duct cancer (cholangiocarcinoma), gallbladder cancer, or ampullary cancer. Bile duct cancer is further divided to intrahepatic, perihilar and distal bile duct subtypes according to the anatomical location of the tumor. The biological characteristics of each tumor are heterogeneous. However, because of the rarity of each disease, the efficacy of new drugs has been tested in groups of patients with different biliary tract cancers. In patients with metastatic or recurrent biliary tract cancer, recent randomized clinical trials revealed the non-inferiority of gemcitabine + S-1 and the superiority of gemcitabine + cisplatin + S-1 compared with gemcitabine + cisplatin in terms of overall survival, thereby establishing a new standard treatment. In the field of adjuvant therapy for biliary tract cancer, the British BILCAP (capecitabine compared with observation in resected biliary tract cancer) study revealed longer median overall survival in the capecitabine group than in the observation group in the per-protocol analysis (but not in the intention-to-treat analysis), bringing a shift toward postoperative management. Several other studies of adjuvant therapy are ongoing, and they may lead to reforms in treatment strategy for resectable biliary tract cancer in the future. The use of neoadjuvant therapy for biliary tract cancer is in its infancy, but it is expected to overcome the limitations of adjuvant therapy for this malignancy. In this review, we summarized the evidence available from clinical trials of adjuvant and neoadjuvant therapy for biliary tract cancer and described ongoing clinical trials.
Bibliographie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
content type line 23
ISSN:1465-3621
1465-3621
DOI:10.1093/jjco/hyaa170