In silico prediction of splice-altering single nucleotide variants in the human genome

In silico tools have been developed to predict variants that may have an impact on pre-mRNA splicing. The major limitation of the application of these tools to basic research and clinical practice is the difficulty in interpreting the output. Most tools only predict potential splice sites given a DN...

Full description

Bibliographic Details

Published in:	Nucleic acids research Vol. 42; no. 22; pp. 13534 - 13544
Main Authors:	Jian, Xueqiu, Boerwinkle, Eric, Liu, Xiaoming
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 16.12.2014
Subjects:	Alternative Splicing Artificial Intelligence Computer Simulation Data Resources and Analyses Genes, Neoplasm Genetic Variation Genome, Human Genomics - methods Humans Position-Specific Scoring Matrices RNA Splice Sites
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
Tags:	Add Tag No Tags, Be the first to tag this record!