Characterization, evolution, and expression analysis of TLR7 gene subfamily members in Mastacembelus armatus (Synbranchiformes: Mastacembelidae)
TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid se...
Uloženo v:
| Vydáno v: | Developmental and comparative immunology Ročník 95; s. 77 - 88 |
|---|---|
| Hlavní autoři: | , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Elsevier Ltd
01.06.2019
Elsevier Science Ltd |
| Témata: | |
| ISSN: | 0145-305X, 1879-0089, 1879-0089 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87.2% and 76.5%, respectively and the identity of MaTLR9 with Seriola lalandi TLR9 was 74.7%. The phylogenetic analysis revealed MaTLRs showed close relationship to other species in Synbranchiformes or Perciformes. Quantitative real-time PCR analysis revealed that they were expressed in all tested tissues and higher expression was found in spleen or gill. After infection with Aeromonas veronii, expression of MaTLR7, MaTLR8 and MaTLR9 were all significantly downregulated in spleen and kidney. Evolutionary analysis suggested that the ancestral lineages of teleost TLR8 and TLR9 had been subject to positive selection pressures and multiple Maximum likelihood methods recovered 3 positively selected sites in teleost TLR7, 4 in TLR8 and 8 in TLR9. Domain distribution revealed most positively selected sites were located in leucine-rich repeat domain. Our results will contribute to better understanding the antibacterial mechanism of TLRs and their co-evolution with pathogens.
•Three new TLRs (MaTLR7, MaTLR8 and MaTLR9) were cloned and characterized from the Zig-zag eel Mastacembelus armatus.•TLR7 subfamily members were expressed in all tested tissues of Mastacembelus armatus.•Expression of three new TLRs significantly downregulated after bacterial infection.•Many positively selected sites were found in teleost TLR7 members especially in LRR domain. |
|---|---|
| AbstractList | TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87.2% and 76.5%, respectively and the identity of MaTLR9 with Seriola lalandi TLR9 was 74.7%. The phylogenetic analysis revealed MaTLRs showed close relationship to other species in Synbranchiformes or Perciformes. Quantitative real-time PCR analysis revealed that they were expressed in all tested tissues and higher expression was found in spleen or gill. After infection with Aeromonas veronii, expression of MaTLR7, MaTLR8 and MaTLR9 were all significantly downregulated in spleen and kidney. Evolutionary analysis suggested that the ancestral lineages of teleost TLR8 and TLR9 had been subject to positive selection pressures and multiple Maximum likelihood methods recovered 3 positively selected sites in teleost TLR7, 4 in TLR8 and 8 in TLR9. Domain distribution revealed most positively selected sites were located in leucine-rich repeat domain. Our results will contribute to better understanding the antibacterial mechanism of TLRs and their co-evolution with pathogens.
•Three new TLRs (MaTLR7, MaTLR8 and MaTLR9) were cloned and characterized from the Zig-zag eel Mastacembelus armatus.•TLR7 subfamily members were expressed in all tested tissues of Mastacembelus armatus.•Expression of three new TLRs significantly downregulated after bacterial infection.•Many positively selected sites were found in teleost TLR7 members especially in LRR domain. TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87.2% and 76.5%, respectively and the identity of MaTLR9 with Seriola lalandi TLR9 was 74.7%. The phylogenetic analysis revealed MaTLRs showed close relationship to other species in Synbranchiformes or Perciformes. Quantitative real-time PCR analysis revealed that they were expressed in all tested tissues and higher expression was found in spleen or gill. After infection with Aeromonas veronii, expression of MaTLR7, MaTLR8 and MaTLR9 were all significantly downregulated in spleen and kidney. Evolutionary analysis suggested that the ancestral lineages of teleost TLR8 and TLR9 had been subject to positive selection pressures and multiple Maximum likelihood methods recovered 3 positively selected sites in teleost TLR7, 4 in TLR8 and 8 in TLR9. Domain distribution revealed most positively selected sites were located in leucine-rich repeat domain. Our results will contribute to better understanding the antibacterial mechanism of TLRs and their co-evolution with pathogens. TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87.2% and 76.5%, respectively and the identity of MaTLR9 with Seriola lalandi TLR9 was 74.7%. The phylogenetic analysis revealed MaTLRs showed close relationship to other species in Synbranchiformes or Perciformes. Quantitative real-time PCR analysis revealed that they were expressed in all tested tissues and higher expression was found in spleen or gill. After infection with Aeromonas veronii, expression of MaTLR7, MaTLR8 and MaTLR9 were all significantly downregulated in spleen and kidney. Evolutionary analysis suggested that the ancestral lineages of teleost TLR8 and TLR9 had been subject to positive selection pressures and multiple Maximum likelihood methods recovered 3 positively selected sites in teleost TLR7, 4 in TLR8 and 8 in TLR9. Domain distribution revealed most positively selected sites were located in leucine-rich repeat domain. Our results will contribute to better understanding the antibacterial mechanism of TLRs and their co-evolution with pathogens.TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study, we successfully identified 3 members of TLR7 subfamily from the spiny eel Mastacembelus armatus (MaTLR7, MaTLR8 and MaTLR9). The amino acid sequence identities of MaTLR7 and MaTLR8 with Monopterus albus TLR7 were 87.2% and 76.5%, respectively and the identity of MaTLR9 with Seriola lalandi TLR9 was 74.7%. The phylogenetic analysis revealed MaTLRs showed close relationship to other species in Synbranchiformes or Perciformes. Quantitative real-time PCR analysis revealed that they were expressed in all tested tissues and higher expression was found in spleen or gill. After infection with Aeromonas veronii, expression of MaTLR7, MaTLR8 and MaTLR9 were all significantly downregulated in spleen and kidney. Evolutionary analysis suggested that the ancestral lineages of teleost TLR8 and TLR9 had been subject to positive selection pressures and multiple Maximum likelihood methods recovered 3 positively selected sites in teleost TLR7, 4 in TLR8 and 8 in TLR9. Domain distribution revealed most positively selected sites were located in leucine-rich repeat domain. Our results will contribute to better understanding the antibacterial mechanism of TLRs and their co-evolution with pathogens. |
| Author | Li, Qiang Hao, Zhiqiang Liu, Jinmei Huang, Jianrong Han, Chong Zhang, Yong |
| Author_xml | – sequence: 1 givenname: Chong surname: Han fullname: Han, Chong organization: State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, PR China – sequence: 2 givenname: Qiang surname: Li fullname: Li, Qiang organization: School of Life Sciences, Guangzhou University, Guangzhou, PR China – sequence: 3 givenname: Jinmei surname: Liu fullname: Liu, Jinmei organization: State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, PR China – sequence: 4 givenname: Zhiqiang surname: Hao fullname: Hao, Zhiqiang organization: State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, PR China – sequence: 5 givenname: Jianrong surname: Huang fullname: Huang, Jianrong email: lsshjr@mail.sysu.edu.cn organization: State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, PR China – sequence: 6 givenname: Yong surname: Zhang fullname: Zhang, Yong email: lsszy@mail.sysu.edu.cn organization: State Key Laboratory of Biocontrol, Institute of Aquatic Economic Animals and Guangdong Provincial Key Laboratory for Aquatic Economic Animals, School of Life Sciences, Sun Yat-Sen University, Guangzhou, PR China |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/30742850$$D View this record in MEDLINE/PubMed |
| BookMark | eNqFkl1rFTEQhoNU7Gn1B3gjAW8quOsk-xm9kkP9gCOCVvAuZJNZm8Nuckx2i6e_wp9s1tOC9KLmZvLC874MM3NCjpx3SMhTBjkDVr_a5kbbnAMTOfAcgD8gK9Y2IgNoxRFZASurrIDq-zE5iXEL6bUMHpHjApqStxWsyO_1pQpKTxjstZqsdy8pXvlhPnyVMxR_7QLGmHSSathHG6nv6cXmS0N_oEMa565Xox32dMSxwxCpdfSTipPSix7mSFUY1ZTq2de964Jy-tL2PowYX_8LWqPwxWPysFdDxCc39ZR8e3d-sf6QbT6__7h-u8l02cKUKVEXKDqsOsFMyWtRA6tKRGFMUxkwJRqtBNeiUyCMqPq6RuSICI3SbVsXp-TskLsL_ueMcZKjjRqHQTn0c5Sc82XGHMr_o6wtWMuaRiT0-R106-eQxrYEQtnUVUpN1LMbau5GNHIX7KjCXt6uJQHNAdDBxxiwl9pOf9czBWUHyUAuzcmtTAcglwOQwGU6gORkd5y34fd53hw8mOZ9ZTHIqC06jcYG1JM03t7j_gMaVMnR |
| CitedBy_id | crossref_primary_10_1016_j_dci_2022_104622 crossref_primary_10_1016_j_ijbiomac_2023_127667 crossref_primary_10_1016_j_fsi_2022_04_035 crossref_primary_10_1111_jfb_15366 crossref_primary_10_3389_fimmu_2025_1555048 crossref_primary_10_1016_j_aquaculture_2020_735550 crossref_primary_10_1016_j_fsi_2020_07_009 crossref_primary_10_3389_fmars_2023_1100949 crossref_primary_10_1016_j_aqrep_2024_102529 crossref_primary_10_1016_j_aqrep_2024_102414 crossref_primary_10_1016_j_dci_2025_105345 crossref_primary_10_1007_s42452_023_05534_1 crossref_primary_10_1016_j_dci_2024_105147 crossref_primary_10_1016_j_dci_2024_105294 |
| Cites_doi | 10.1006/meth.2001.1262 10.1093/nar/gkq443 10.1038/nri1391 10.1016/j.dci.2016.05.001 10.1086/338628 10.1016/j.fsi.2013.05.019 10.1016/S0044-8486(99)00187-8 10.1093/sysbio/syq010 10.1093/molbev/msq115 10.1016/j.molimm.2003.10.003 10.1007/s11033-012-1765-y 10.1093/nar/gkr931 10.1016/j.vetimm.2015.10.006 10.1093/molbev/msm088 10.1016/j.dci.2009.10.002 10.1016/j.cell.2006.02.015 10.1038/nmeth0410-248 10.1016/S1471-4906(03)00242-4 10.1016/j.imlet.2013.11.013 10.1016/j.fsi.2017.07.014 10.1016/S0092-8674(00)80412-2 10.1038/ni.1863 10.1101/gr.849004 10.1093/bioinformatics/bti320 10.1093/nar/25.24.4876 10.1016/j.dci.2016.03.005 10.1016/j.fsi.2015.06.023 10.1016/j.fsi.2017.02.021 10.1016/j.fsi.2007.11.005 10.1186/1471-2105-10-S15-S2 10.3109/19401736.2014.892102 10.1016/j.fsi.2017.11.044 10.1038/nprot.2009.86 10.1016/j.dci.2009.04.007 10.1016/j.fsi.2014.09.022 10.1016/j.dci.2013.01.009 10.1016/j.fsi.2013.04.043 10.1126/science.1093620 10.14798/73.3.820 10.1016/j.vetimm.2009.09.021 10.1093/molbev/msr272 10.1016/j.dci.2017.08.007 10.1016/j.fsi.2017.02.026 10.1016/j.fsi.2016.09.021 10.1016/S0022-2836(05)80360-2 |
| ContentType | Journal Article |
| Copyright | 2019 Elsevier Ltd Copyright © 2019 Elsevier Ltd. All rights reserved. Copyright Elsevier Science Ltd. Jun 2019 |
| Copyright_xml | – notice: 2019 Elsevier Ltd – notice: Copyright © 2019 Elsevier Ltd. All rights reserved. – notice: Copyright Elsevier Science Ltd. Jun 2019 |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM 7QL 7T5 C1K H94 7X8 7S9 L.6 |
| DOI | 10.1016/j.dci.2019.02.002 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Bacteriology Abstracts (Microbiology B) Immunology Abstracts Environmental Sciences and Pollution Management AIDS and Cancer Research Abstracts MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) AIDS and Cancer Research Abstracts Immunology Abstracts Bacteriology Abstracts (Microbiology B) Environmental Sciences and Pollution Management MEDLINE - Academic AGRICOLA AGRICOLA - Academic |
| DatabaseTitleList | AIDS and Cancer Research Abstracts MEDLINE - Academic MEDLINE AGRICOLA |
| Database_xml | – sequence: 1 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 2 dbid: 7X8 name: MEDLINE - Academic url: https://search.proquest.com/medline sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Medicine Biology |
| EISSN | 1879-0089 |
| EndPage | 88 |
| ExternalDocumentID | 30742850 10_1016_j_dci_2019_02_002 S0145305X18305603 |
| Genre | Research Support, Non-U.S. Gov't Journal Article |
| GroupedDBID | --- --K --M .GJ .~1 0R~ 1B1 1RT 1~. 1~5 29F 4.4 457 4G. 53G 5GY 5RE 5VS 7-5 71M 8P~ 9JM AAAJQ AACTN AAEDT AAEDW AAIAV AAIKJ AAKOC AALRI AAOAW AAQFI AAQXK AARKO AAXUO ABBQC ABFNM ABGSF ABJNI ABKYH ABLVK ABMAC ABMZM ABRWV ABUDA ABXDB ABYKQ ACDAQ ACGFO ACGFS ACIUM ACPRK ACRLP ADBBV ADEZE ADMUD ADUVX AEBSH AEHWI AEKER AENEX AESVU AEXOQ AFKWA AFRAH AFTJW AFXIZ AGEKW AGHFR AGRDE AGUBO AGYEJ AHHHB AIEXJ AIKHN AITUG AJBFU AJOXV AJRQY ALMA_UNASSIGNED_HOLDINGS AMFUW AMRAJ ANZVX ASPBG AVWKF AXJTR AZFZN BKOJK BLXMC BNPGV C45 CJTIS CNWQP CS3 DOVZS EBS EFJIC EFLBG EJD EO8 EO9 EP2 EP3 F5P FDB FEDTE FGOYB FIRID FNPLU FYGXN G-2 G-Q GBLVA HLV HMG HVGLF HZ~ IHE J1W K-O KOM L7B LCYCR LUGTX LW9 M41 MO0 N9A O-L O9- OAUVE OVD OZT P-8 P-9 P2P PC. Q38 QYZTP R2- RIG ROL RPZ SAB SDF SDG SES SEW SIN SNL SPCBC SSH SSI SSU SSZ T5K TEORI WUQ ZGI ~G- ~KM 9DU AAHBH AATTM AAXKI AAYWO AAYXX ABWVN ACIEU ACLOT ACMHX ACRPL ACVFH ADCNI ADNMO ADSLC AEIPS AEUPX AFJKZ AFPUW AGQPQ AGWPP AIGII AIIUN AKBMS AKRWK AKYEP ANKPU APXCP CITATION EFKBS ~HD AGCQF AGRNS CGR CUY CVF ECM EIF NPM 7QL 7T5 C1K H94 7X8 7S9 L.6 |
| ID | FETCH-LOGICAL-c480t-a963e9be5b91d426960154ee9dd75d0d4edca92c9ba09d95f66ee2eee07ac8863 |
| ISICitedReferencesCount | 13 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000462107900009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 0145-305X 1879-0089 |
| IngestDate | Thu Oct 02 11:35:51 EDT 2025 Thu Oct 02 11:30:15 EDT 2025 Wed Aug 13 06:17:26 EDT 2025 Mon Jul 21 06:02:20 EDT 2025 Sat Nov 29 02:29:43 EST 2025 Tue Nov 18 21:50:12 EST 2025 Fri Feb 23 02:25:33 EST 2024 |
| IsPeerReviewed | true |
| IsScholarly | true |
| Keywords | PBS PP ORF Positive selection FUBAR TLR7 subfamily qRT-PCR Mastacembelus armatus FEL LRR LRT PRR PAMP Aeromonas veronii UTR MEME NLR RLR TM TLR TIR SLAC |
| Language | English |
| License | Copyright © 2019 Elsevier Ltd. All rights reserved. |
| LinkModel | OpenURL |
| MergedId | FETCHMERGED-LOGICAL-c480t-a963e9be5b91d426960154ee9dd75d0d4edca92c9ba09d95f66ee2eee07ac8863 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 |
| PMID | 30742850 |
| PQID | 2204765210 |
| PQPubID | 2047473 |
| PageCount | 12 |
| ParticipantIDs | proquest_miscellaneous_2221016204 proquest_miscellaneous_2183181779 proquest_journals_2204765210 pubmed_primary_30742850 crossref_citationtrail_10_1016_j_dci_2019_02_002 crossref_primary_10_1016_j_dci_2019_02_002 elsevier_sciencedirect_doi_10_1016_j_dci_2019_02_002 |
| PublicationCentury | 2000 |
| PublicationDate | 2019-06-01 |
| PublicationDateYYYYMMDD | 2019-06-01 |
| PublicationDate_xml | – month: 06 year: 2019 text: 2019-06-01 day: 01 |
| PublicationDecade | 2010 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: Oxford |
| PublicationTitle | Developmental and comparative immunology |
| PublicationTitleAlternate | Dev Comp Immunol |
| PublicationYear | 2019 |
| Publisher | Elsevier Ltd Elsevier Science Ltd |
| Publisher_xml | – name: Elsevier Ltd – name: Elsevier Science Ltd |
| References | Rauta, Samanta, Dash, Nayak, Das (bib32) 2014; 158 Zhang, Liu, Li, Ren, Lin, Shi, Wu (bib45) 2015; 34 Medzhitov, Janeway (bib25) 1997; 91 Palti, Gahr, Purcell, Hadidi, Rexroad, Wiens (bib27) 2010; 34 Gatesoupe, Brunt (bib13) 1999; 180 Zhu, Sun, Wang, Xu (bib44) 2013; 35 Han, Li, Zhang, Huang (bib15) 2017; 77 Zhang, Zhang, Shi, Yuan, Zheng, Lin, Wei, Ji (bib48) 2017; 63 Kumar, Henikoff, Ng (bib21) 2009; 4 Crooks, Hon, Chandonia, Brenner (bib7) 2004; 14 Wang, Bi, Chu, Xu (bib40) 2016; 61 Qi, Xia, Chao, Zhao, Wu (bib31) 2017; 68 Fletcher, Yang (bib11) 2010; 27 Skjaeveland, Iliev, Strandskog, Jorgensen (bib34) 2009; 33 Letunic, Doerks, Bork (bib22) 2012; 40 Heil, Hemmi, Hochrein, Ampenberger, Kirschning, Akira, Lipford, Wagner, Bauer (bib17) 2004; 303 Adzhubei, Schmidt, Peshkin, Ramensky, Gerasimova, Bork, Kondrashov, Sunyaev (bib1) 2010; 7 Fan, Zhou, Zeng, Jiang, Liu, Zhao, Zhong (bib10) 2018; 72 Chen, Wang, Tzeng, Wang, Wang (bib6) 2008; 24 Livak, Schmittgen (bib24) 2001; 25 Meijer, Krens, Rodriguez, He, Bitter, Snaar-Jagalska, Spaink (bib26) 2004; 40 Bell, Mullen, Leifer, Mazzoni, Davies, Segal (bib5) 2003; 24 Akira, Uematsu, Takeuchi (bib3) 2006; 124 Wang, Li, Han, Shu, Xu (bib39) 2016; 62 Choo, Tan, Ranganathan (bib8) 2009; 10 Jordan, Goldman (bib19) 2011; 29 Yang (bib43) 2007; 24 Tanekhy, Kono, Sakai (bib36) 2010; 5 Pond, Frost (bib29) 2005; 21 Tong, Lin, Zhang, Shi, Qi, Zhao (bib38) 2015; 46 Wei, Hu, Sun, Zhang, Qiao, Wang, Shao, Huang, Qi (bib41) 2017; 63 Zhang, Kong, Zhou, Li, Nie, Li (bib47) 2014; 41 (bib12) 2017 Penn, Privman, Ashkenazy, Landan, Graur, Pupko (bib28) 2010; 38 Guindon, Dufayard, Lefort, Anisimova, Hordijk, Gascuel (bib14) 2010; 59 Dong, Su, Zhou, Shang, Yan, Liu, Gao, Tan, Li (bib9) 2016; 58 Thompson, Gibson, Plewniak, Jeanmougin, Higgins (bib37) 1997; 25 Sundaram, Consuegra, Kiron, Fernandes (bib35) 2012; 39 Altschul, Gish, Miller, Myers, Lipman (bib4) 1990; 215 Hossain, Hossen, Yahya, Ahmed, Sarder, Islam, Ahmed (bib18) 2016; 73 Zhang, Liu, Rajendran, Sun, Zhang, Sun, Kucuktas, Liu, Liu (bib46) 2013; 40 Wei, Jia, Tong, Wang, Zheng, He, Yang, Liu (bib42) 2016; 170 Kawai, Akira (bib20) 2010; 11 Rebl, Goldammer, Seyfert (bib33) 2010; 134 Qian, Wang, Mu, Ao, Chen (bib30) 2013; 35 Li, Xu, Shu, Chen, Huang (bib23) 2016; 27 Akira, Takeda (bib2) 2004; 4 Hamblin, Thompson, Di Rienzo (bib16) 2002; 70 Han (10.1016/j.dci.2019.02.002_bib15) 2017; 77 Heil (10.1016/j.dci.2019.02.002_bib17) 2004; 303 Guindon (10.1016/j.dci.2019.02.002_bib14) 2010; 59 Wei (10.1016/j.dci.2019.02.002_bib42) 2016; 170 Qian (10.1016/j.dci.2019.02.002_bib30) 2013; 35 Yang (10.1016/j.dci.2019.02.002_bib43) 2007; 24 Hamblin (10.1016/j.dci.2019.02.002_bib16) 2002; 70 Fletcher (10.1016/j.dci.2019.02.002_bib11) 2010; 27 Hossain (10.1016/j.dci.2019.02.002_bib18) 2016; 73 Zhang (10.1016/j.dci.2019.02.002_bib46) 2013; 40 Crooks (10.1016/j.dci.2019.02.002_bib7) 2004; 14 Medzhitov (10.1016/j.dci.2019.02.002_bib25) 1997; 91 Wei (10.1016/j.dci.2019.02.002_bib41) 2017; 63 Kawai (10.1016/j.dci.2019.02.002_bib20) 2010; 11 Rauta (10.1016/j.dci.2019.02.002_bib32) 2014; 158 Qi (10.1016/j.dci.2019.02.002_bib31) 2017; 68 Akira (10.1016/j.dci.2019.02.002_bib2) 2004; 4 Letunic (10.1016/j.dci.2019.02.002_bib22) 2012; 40 Rebl (10.1016/j.dci.2019.02.002_bib33) 2010; 134 Bell (10.1016/j.dci.2019.02.002_bib5) 2003; 24 Kumar (10.1016/j.dci.2019.02.002_bib21) 2009; 4 Tanekhy (10.1016/j.dci.2019.02.002_bib36) 2010; 5 Adzhubei (10.1016/j.dci.2019.02.002_bib1) 2010; 7 Gatesoupe (10.1016/j.dci.2019.02.002_bib13) 1999; 180 Li (10.1016/j.dci.2019.02.002_bib23) 2016; 27 Pond (10.1016/j.dci.2019.02.002_bib29) 2005; 21 Zhang (10.1016/j.dci.2019.02.002_bib48) 2017; 63 Sundaram (10.1016/j.dci.2019.02.002_bib35) 2012; 39 Jordan (10.1016/j.dci.2019.02.002_bib19) 2011; 29 Wang (10.1016/j.dci.2019.02.002_bib39) 2016; 62 Penn (10.1016/j.dci.2019.02.002_bib28) 2010; 38 Dong (10.1016/j.dci.2019.02.002_bib9) 2016; 58 Akira (10.1016/j.dci.2019.02.002_bib3) 2006; 124 Palti (10.1016/j.dci.2019.02.002_bib27) 2010; 34 Skjaeveland (10.1016/j.dci.2019.02.002_bib34) 2009; 33 Wang (10.1016/j.dci.2019.02.002_bib40) 2016; 61 Tong (10.1016/j.dci.2019.02.002_bib38) 2015; 46 Zhang (10.1016/j.dci.2019.02.002_bib45) 2015; 34 Livak (10.1016/j.dci.2019.02.002_bib24) 2001; 25 Zhang (10.1016/j.dci.2019.02.002_bib47) 2014; 41 Choo (10.1016/j.dci.2019.02.002_bib8) 2009; 10 Fan (10.1016/j.dci.2019.02.002_bib10) 2018; 72 Chen (10.1016/j.dci.2019.02.002_bib6) 2008; 24 (10.1016/j.dci.2019.02.002_bib12) 2017 Thompson (10.1016/j.dci.2019.02.002_bib37) 1997; 25 Zhu (10.1016/j.dci.2019.02.002_bib44) 2013; 35 Altschul (10.1016/j.dci.2019.02.002_bib4) 1990; 215 Meijer (10.1016/j.dci.2019.02.002_bib26) 2004; 40 |
| References_xml | – volume: 14 start-page: 1188 year: 2004 end-page: 1190 ident: bib7 article-title: WebLogo: a sequence logo generator publication-title: Genome Res. – volume: 72 start-page: 629 year: 2018 end-page: 638 ident: bib10 article-title: Identification, structural characterization, and expression analysis of toll-like receptors 2 and 3 from gibel carp ( publication-title: Fish Shellfish Immunol. – volume: 29 start-page: 1125 year: 2011 end-page: 1139 ident: bib19 article-title: The effects of alignment error and alignment filtering on the sitewise detection of positive selection publication-title: Mol. Biol. Evol. – volume: 70 start-page: 369 year: 2002 end-page: 383 ident: bib16 article-title: Complex signatures of natural selection at the Duffy blood group locus publication-title: Am. J. Hum. Genet. – volume: 40 start-page: 773 year: 2004 end-page: 783 ident: bib26 article-title: Expression analysis of the toll-like receptor and tir domain adaptor families of zebrafish publication-title: Mol. Immunol. – volume: 24 start-page: 234 year: 2008 end-page: 242 ident: bib6 article-title: Evidence for positive selection in the TLR9 gene of teleosts publication-title: Fish Shellfish Immunol. – volume: 27 start-page: 2257 year: 2010 end-page: 2267 ident: bib11 article-title: The effect of insertions, deletions, and alignment errors on the branch-site test of positive selection publication-title: Mol. Biol. Evol. – volume: 38 start-page: W23 year: 2010 end-page: W28 ident: bib28 article-title: GUIDANCE: a web server for assessing alignment confidence scores publication-title: Nucleic Acids Res. – volume: 62 start-page: 102 year: 2016 end-page: 107 ident: bib39 article-title: Identification and characteristic analysis of TLR28: a novel member of the TLR1 family in teleost publication-title: Dev. Comp. Immunol. – volume: 63 start-page: 270 year: 2017 end-page: 276 ident: bib41 article-title: Molecular cloning and expression analysis of toll-like receptor genes (tlr7, tlr8 and tlr9) of golden pompano ( publication-title: Fish Shellfish Immunol. – volume: 24 start-page: 528 year: 2003 end-page: 533 ident: bib5 article-title: Leucine-rich repeats and pathogen recognition in toll-like receptors publication-title: Trends Immunol. – volume: 40 start-page: 302 year: 2012 end-page: 305 ident: bib22 article-title: SMART 7: recent updates to the protein domain annotation resource publication-title: Nucleic Acids Res. – volume: 35 start-page: 671 year: 2013 end-page: 679 ident: bib30 article-title: Molecular characterization and expression analysis of tlr 7 and tlr 8 homologs in large yellow croaker ( publication-title: Fish Shellfish Immunol. – volume: 7 start-page: 248 year: 2010 end-page: 249 ident: bib1 article-title: A method and server for predicting damaging missense mutations publication-title: Nat. Methods – volume: 25 start-page: 402 year: 2001 end-page: 408 ident: bib24 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method publication-title: Methods – volume: 5 start-page: 245 year: 2010 end-page: 255 ident: bib36 article-title: Cloning, characterization, and expression analysis of toll-like receptor-7 cdna from common carp, Cyprinus carpio L publication-title: Comp. Biochem. Physiol. B – volume: 68 start-page: 102 year: 2017 end-page: 113 ident: bib31 article-title: Identification, molecular evolution of toll-like receptors in a Tibetan schizothoracine fish ( publication-title: Fish Shellfish Immunol. – volume: 63 start-page: 384 year: 2017 end-page: 393 ident: bib48 article-title: Expression analysis of nine toll-like receptors in yellow catfish ( publication-title: Fish Shellfish Immunol. – volume: 10 start-page: S2 year: 2009 ident: bib8 article-title: A comprehensive assessment of N-terminal signal peptides prediction methods publication-title: BMC Bioinf. – volume: 303 start-page: 1526 year: 2004 end-page: 1529 ident: bib17 article-title: Species-specific recognition of single-stranded rna via toll-like receptor 7 and 8 publication-title: Science – volume: 58 start-page: 309 year: 2016 end-page: 317 ident: bib9 article-title: Identification and expression analysis of toll-like receptor genes (tlr8 and tlr9) in mucosal tissues of turbot ( publication-title: Fish Shellfish Immunol. – volume: 134 start-page: 139 year: 2010 end-page: 150 ident: bib33 article-title: Toll-like receptor signaling in bony fish publication-title: Vet. Immunol. Immunopathol. – volume: 4 start-page: 499 year: 2004 end-page: 511 ident: bib2 article-title: Toll-like receptor signaling publication-title: Nat. Rev. Immunol. – volume: 180 start-page: 147 year: 1999 end-page: 165 ident: bib13 article-title: The use of probiotics in aquaculture publication-title: Aquaculture – volume: 24 start-page: 1586 year: 2007 end-page: 1591 ident: bib43 article-title: PAML 4: phylogenetic analysis by maximum likelihood publication-title: Mol. Biol. Evol. – volume: 25 start-page: 4876 year: 1997 end-page: 4882 ident: bib37 article-title: The clustal_x windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools publication-title: Nucleic Acids Res. – volume: 34 start-page: 673 year: 2015 end-page: 682 ident: bib45 article-title: Epidemic characteristics of different species of publication-title: Fish. Sci. – volume: 73 start-page: 137 year: 2016 end-page: 139 ident: bib18 article-title: Threatened fishes of the world: publication-title: Croat. J. Fish. – volume: 33 start-page: 1011 year: 2009 end-page: 1017 ident: bib34 article-title: Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon ( publication-title: Dev. Comp. Immunol. – volume: 215 start-page: 403 year: 1990 end-page: 410 ident: bib4 article-title: Basic local alignment search tool publication-title: J. Mol. Biol. – volume: 27 start-page: 330 year: 2016 end-page: 331 ident: bib23 article-title: The complete mitochondrial genome of the zig-zag eel publication-title: Mitochondrial DNA part A – volume: 77 start-page: 174 year: 2017 end-page: 187 ident: bib15 article-title: Characterization, expression, and evolutionary analysis of new tlr3 and tlr5m genes cloned from the spiny eel publication-title: Dev. Comp. Immunol. – volume: 158 start-page: 14 year: 2014 end-page: 24 ident: bib32 article-title: Toll-like receptors (TLRs) in aquatic animals: signaling pathways, expressions and immune responses publication-title: Immunol. Lett. – volume: 21 start-page: 2531 year: 2005 end-page: 2533 ident: bib29 article-title: Datamonkey: rapid detection of selective pressure on individual sites of codon alignments publication-title: Bioinformatics – volume: 124 start-page: 783 year: 2006 end-page: 801 ident: bib3 article-title: Pathogen recognition and innate immunity publication-title: Cell – volume: 40 start-page: 185 year: 2013 end-page: 194 ident: bib46 article-title: Pathogen recognition receptors in channel catfish: iii phylogeny and expression analysis of toll-like receptors publication-title: Dev. Comp. Immunol. – volume: 46 start-page: 334 year: 2015 end-page: 345 ident: bib38 article-title: Transcriptome-wide identification, molecular evolution and expression analysis of Toll-like receptor family in a Tibet fish, publication-title: Fish Shellfish Immunol. – volume: 35 start-page: 448 year: 2013 end-page: 457 ident: bib44 article-title: Evolutionary analysis of TLR9 genes reveals the positive selection of extant teleosts in Perciformes publication-title: Fish Shellfish Immunol. – volume: 170 start-page: 47 year: 2016 end-page: 53 ident: bib42 article-title: Effect of common carp ( publication-title: Vet. Immunol. Immunopathol. – volume: 59 start-page: 307 year: 2010 end-page: 321 ident: bib14 article-title: New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 publication-title: Syst. Biol. – volume: 34 start-page: 219 year: 2010 end-page: 233 ident: bib27 article-title: Identification,characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2genes in rainbow trout ( publication-title: Dev. Comp. Immunol. – volume: 41 start-page: 380 year: 2014 end-page: 388 ident: bib47 article-title: Toll-like receptor recognition of bacteria in fish: ligand specificity and signal pathways publication-title: Fish Shellfish Immunol. – volume: 4 start-page: 1073 year: 2009 end-page: 1081 ident: bib21 article-title: Predicting the effects of coding non-synonymous variants on protein function using the sift algorithm publication-title: Nat. Protoc. – volume: 91 start-page: 295 year: 1997 end-page: 298 ident: bib25 article-title: Innate immunity: the virtues of a nonclonal system of recognition publication-title: Cell – volume: 61 start-page: 25 year: 2016 end-page: 33 ident: bib40 article-title: Discovery of toll-like receptor 13 exists in the teleost fish: miiuy croaker (perciformes, sciaenidae) publication-title: Dev. Comp. Immunol. – year: 2017 ident: bib12 publication-title: FishBase. World Wide Web Electronic Publication – volume: 11 start-page: 373 year: 2010 end-page: 384 ident: bib20 article-title: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors publication-title: Nat. Immunol. – volume: 39 start-page: 8965 year: 2012 end-page: 8975 ident: bib35 article-title: Positive selection pressure within teleost toll-like receptors tlr21 and tlr22 subfamilies and their response to temperature stress and microbial components in zebrafish publication-title: Mol. Biol. Rep. – volume: 25 start-page: 402 year: 2001 ident: 10.1016/j.dci.2019.02.002_bib24 article-title: Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C (T)) Method publication-title: Methods doi: 10.1006/meth.2001.1262 – volume: 38 start-page: W23 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib28 article-title: GUIDANCE: a web server for assessing alignment confidence scores publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkq443 – volume: 4 start-page: 499 year: 2004 ident: 10.1016/j.dci.2019.02.002_bib2 article-title: Toll-like receptor signaling publication-title: Nat. Rev. Immunol. doi: 10.1038/nri1391 – volume: 62 start-page: 102 year: 2016 ident: 10.1016/j.dci.2019.02.002_bib39 article-title: Identification and characteristic analysis of TLR28: a novel member of the TLR1 family in teleost publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2016.05.001 – volume: 70 start-page: 369 year: 2002 ident: 10.1016/j.dci.2019.02.002_bib16 article-title: Complex signatures of natural selection at the Duffy blood group locus publication-title: Am. J. Hum. Genet. doi: 10.1086/338628 – volume: 35 start-page: 671 year: 2013 ident: 10.1016/j.dci.2019.02.002_bib30 article-title: Molecular characterization and expression analysis of tlr 7 and tlr 8 homologs in large yellow croaker (Pseudosciaena crocea) publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2013.05.019 – volume: 180 start-page: 147 year: 1999 ident: 10.1016/j.dci.2019.02.002_bib13 article-title: The use of probiotics in aquaculture publication-title: Aquaculture doi: 10.1016/S0044-8486(99)00187-8 – volume: 59 start-page: 307 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib14 article-title: New algorithms and methods to estimate maximum-likelihood phylogenies: assessing the performance of PhyML 3.0 publication-title: Syst. Biol. doi: 10.1093/sysbio/syq010 – volume: 27 start-page: 2257 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib11 article-title: The effect of insertions, deletions, and alignment errors on the branch-site test of positive selection publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msq115 – volume: 40 start-page: 773 year: 2004 ident: 10.1016/j.dci.2019.02.002_bib26 article-title: Expression analysis of the toll-like receptor and tir domain adaptor families of zebrafish publication-title: Mol. Immunol. doi: 10.1016/j.molimm.2003.10.003 – volume: 39 start-page: 8965 year: 2012 ident: 10.1016/j.dci.2019.02.002_bib35 article-title: Positive selection pressure within teleost toll-like receptors tlr21 and tlr22 subfamilies and their response to temperature stress and microbial components in zebrafish publication-title: Mol. Biol. Rep. doi: 10.1007/s11033-012-1765-y – volume: 40 start-page: 302 issue: Database issue year: 2012 ident: 10.1016/j.dci.2019.02.002_bib22 article-title: SMART 7: recent updates to the protein domain annotation resource publication-title: Nucleic Acids Res. doi: 10.1093/nar/gkr931 – volume: 170 start-page: 47 year: 2016 ident: 10.1016/j.dci.2019.02.002_bib42 article-title: Effect of common carp (Cyprinus carpio) tlr9 overexpression on the expression of downstream interferon-associated immune factor mrnas in epithelioma papulosum cyprini cells publication-title: Vet. Immunol. Immunopathol. doi: 10.1016/j.vetimm.2015.10.006 – volume: 24 start-page: 1586 year: 2007 ident: 10.1016/j.dci.2019.02.002_bib43 article-title: PAML 4: phylogenetic analysis by maximum likelihood publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msm088 – volume: 34 start-page: 673 year: 2015 ident: 10.1016/j.dci.2019.02.002_bib45 article-title: Epidemic characteristics of different species of Aeromonas in diseased fish in southern China publication-title: Fish. Sci. – volume: 34 start-page: 219 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib27 article-title: Identification,characterization and genetic mapping of TLR7, TLR8a1 and TLR8a2genes in rainbow trout (Oncorhynchus mykiss) publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2009.10.002 – volume: 124 start-page: 783 year: 2006 ident: 10.1016/j.dci.2019.02.002_bib3 article-title: Pathogen recognition and innate immunity publication-title: Cell doi: 10.1016/j.cell.2006.02.015 – volume: 7 start-page: 248 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib1 article-title: A method and server for predicting damaging missense mutations publication-title: Nat. Methods doi: 10.1038/nmeth0410-248 – volume: 24 start-page: 528 year: 2003 ident: 10.1016/j.dci.2019.02.002_bib5 article-title: Leucine-rich repeats and pathogen recognition in toll-like receptors publication-title: Trends Immunol. doi: 10.1016/S1471-4906(03)00242-4 – volume: 158 start-page: 14 year: 2014 ident: 10.1016/j.dci.2019.02.002_bib32 article-title: Toll-like receptors (TLRs) in aquatic animals: signaling pathways, expressions and immune responses publication-title: Immunol. Lett. doi: 10.1016/j.imlet.2013.11.013 – volume: 68 start-page: 102 year: 2017 ident: 10.1016/j.dci.2019.02.002_bib31 article-title: Identification, molecular evolution of toll-like receptors in a Tibetan schizothoracine fish (Gymnocypris eckloni) and their expression profiles in response to acute hypoxia publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2017.07.014 – volume: 91 start-page: 295 year: 1997 ident: 10.1016/j.dci.2019.02.002_bib25 article-title: Innate immunity: the virtues of a nonclonal system of recognition publication-title: Cell doi: 10.1016/S0092-8674(00)80412-2 – volume: 11 start-page: 373 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib20 article-title: The role of pattern-recognition receptors in innate immunity: update on Toll-like receptors publication-title: Nat. Immunol. doi: 10.1038/ni.1863 – volume: 14 start-page: 1188 year: 2004 ident: 10.1016/j.dci.2019.02.002_bib7 article-title: WebLogo: a sequence logo generator publication-title: Genome Res. doi: 10.1101/gr.849004 – volume: 21 start-page: 2531 year: 2005 ident: 10.1016/j.dci.2019.02.002_bib29 article-title: Datamonkey: rapid detection of selective pressure on individual sites of codon alignments publication-title: Bioinformatics doi: 10.1093/bioinformatics/bti320 – volume: 25 start-page: 4876 year: 1997 ident: 10.1016/j.dci.2019.02.002_bib37 article-title: The clustal_x windows interface: flexible strategies for multiple sequence alignment aided by quality analysis tools publication-title: Nucleic Acids Res. doi: 10.1093/nar/25.24.4876 – volume: 61 start-page: 25 year: 2016 ident: 10.1016/j.dci.2019.02.002_bib40 article-title: Discovery of toll-like receptor 13 exists in the teleost fish: miiuy croaker (perciformes, sciaenidae) publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2016.03.005 – volume: 46 start-page: 334 year: 2015 ident: 10.1016/j.dci.2019.02.002_bib38 article-title: Transcriptome-wide identification, molecular evolution and expression analysis of Toll-like receptor family in a Tibet fish, Gymnocypris przewalskii publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2015.06.023 – volume: 5 start-page: 245 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib36 article-title: Cloning, characterization, and expression analysis of toll-like receptor-7 cdna from common carp, Cyprinus carpio L publication-title: Comp. Biochem. Physiol. B – volume: 63 start-page: 384 year: 2017 ident: 10.1016/j.dci.2019.02.002_bib48 article-title: Expression analysis of nine toll-like receptors in yellow catfish (Pelteobagrus fulvidraco) responding to Aeromonas hydrophila challenge publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2017.02.021 – volume: 24 start-page: 234 year: 2008 ident: 10.1016/j.dci.2019.02.002_bib6 article-title: Evidence for positive selection in the TLR9 gene of teleosts publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2007.11.005 – volume: 10 start-page: S2 year: 2009 ident: 10.1016/j.dci.2019.02.002_bib8 article-title: A comprehensive assessment of N-terminal signal peptides prediction methods publication-title: BMC Bioinf. doi: 10.1186/1471-2105-10-S15-S2 – volume: 27 start-page: 330 year: 2016 ident: 10.1016/j.dci.2019.02.002_bib23 article-title: The complete mitochondrial genome of the zig-zag eel Mastacembelus armatus (teleostei, mastacembelidae) publication-title: Mitochondrial DNA part A doi: 10.3109/19401736.2014.892102 – volume: 72 start-page: 629 year: 2018 ident: 10.1016/j.dci.2019.02.002_bib10 article-title: Identification, structural characterization, and expression analysis of toll-like receptors 2 and 3 from gibel carp (Carassius auratus gibelio) [J] publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2017.11.044 – volume: 4 start-page: 1073 year: 2009 ident: 10.1016/j.dci.2019.02.002_bib21 article-title: Predicting the effects of coding non-synonymous variants on protein function using the sift algorithm publication-title: Nat. Protoc. doi: 10.1038/nprot.2009.86 – volume: 33 start-page: 1011 year: 2009 ident: 10.1016/j.dci.2019.02.002_bib34 article-title: Identification and characterization of TLR8 and MyD88 homologs in Atlantic salmon (Salmo salar) publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2009.04.007 – volume: 41 start-page: 380 year: 2014 ident: 10.1016/j.dci.2019.02.002_bib47 article-title: Toll-like receptor recognition of bacteria in fish: ligand specificity and signal pathways publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2014.09.022 – volume: 40 start-page: 185 year: 2013 ident: 10.1016/j.dci.2019.02.002_bib46 article-title: Pathogen recognition receptors in channel catfish: iii phylogeny and expression analysis of toll-like receptors publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2013.01.009 – volume: 35 start-page: 448 year: 2013 ident: 10.1016/j.dci.2019.02.002_bib44 article-title: Evolutionary analysis of TLR9 genes reveals the positive selection of extant teleosts in Perciformes publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2013.04.043 – volume: 303 start-page: 1526 year: 2004 ident: 10.1016/j.dci.2019.02.002_bib17 article-title: Species-specific recognition of single-stranded rna via toll-like receptor 7 and 8 publication-title: Science doi: 10.1126/science.1093620 – volume: 73 start-page: 137 year: 2016 ident: 10.1016/j.dci.2019.02.002_bib18 article-title: Threatened fishes of the world: Mastacembelus armatus (lacépède, 1800) (synbranchiformes: mastacembelidae) publication-title: Croat. J. Fish. doi: 10.14798/73.3.820 – volume: 134 start-page: 139 year: 2010 ident: 10.1016/j.dci.2019.02.002_bib33 article-title: Toll-like receptor signaling in bony fish publication-title: Vet. Immunol. Immunopathol. doi: 10.1016/j.vetimm.2009.09.021 – volume: 29 start-page: 1125 year: 2011 ident: 10.1016/j.dci.2019.02.002_bib19 article-title: The effects of alignment error and alignment filtering on the sitewise detection of positive selection publication-title: Mol. Biol. Evol. doi: 10.1093/molbev/msr272 – volume: 77 start-page: 174 year: 2017 ident: 10.1016/j.dci.2019.02.002_bib15 article-title: Characterization, expression, and evolutionary analysis of new tlr3 and tlr5m genes cloned from the spiny eel Mastacembelus armatus publication-title: Dev. Comp. Immunol. doi: 10.1016/j.dci.2017.08.007 – volume: 63 start-page: 270 year: 2017 ident: 10.1016/j.dci.2019.02.002_bib41 article-title: Molecular cloning and expression analysis of toll-like receptor genes (tlr7, tlr8 and tlr9) of golden pompano (Trachinotus ovatus) publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2017.02.026 – year: 2017 ident: 10.1016/j.dci.2019.02.002_bib12 – volume: 58 start-page: 309 year: 2016 ident: 10.1016/j.dci.2019.02.002_bib9 article-title: Identification and expression analysis of toll-like receptor genes (tlr8 and tlr9) in mucosal tissues of turbot (Scophthalmus maximus L.) following bacterial challenge publication-title: Fish Shellfish Immunol. doi: 10.1016/j.fsi.2016.09.021 – volume: 215 start-page: 403 year: 1990 ident: 10.1016/j.dci.2019.02.002_bib4 article-title: Basic local alignment search tool publication-title: J. Mol. Biol. doi: 10.1016/S0022-2836(05)80360-2 |
| SSID | ssj0000810 |
| Score | 2.3495238 |
| Snippet | TLR7 subfamily members are important pattern recognition receptors participating in the recognition of pathogen-associated molecular patterns. In this study,... |
| SourceID | proquest pubmed crossref elsevier |
| SourceType | Aggregation Database Index Database Enrichment Source Publisher |
| StartPage | 77 |
| SubjectTerms | Aeromonas veronii Aeromonas veronii - immunology Aeromonas veronii - pathogenicity Amino acid sequence Amino Acid Sequence - genetics amino acid sequences Amino acids Animals Biological Coevolution - genetics Biological Coevolution - immunology coevolution eel Evolution Evolution, Molecular Fish Diseases - immunology Fish Diseases - microbiology Fish Proteins - genetics Gene expression genes Gram-Negative Bacterial Infections - immunology Gram-Negative Bacterial Infections - microbiology Host-Pathogen Interactions - genetics Host-Pathogen Interactions - immunology Immunity, Innate - genetics kidneys Leucine Mastacembelus armatus Monopterus albus pathogen-associated molecular patterns Pathogens Pattern recognition Pattern recognition receptors Phylogeny Positive selection Protein Domains - genetics Protein Domains - immunology quantitative polymerase chain reaction Receptors Selection, Genetic Seriola lalandi Smegmamorpha - genetics Smegmamorpha - immunology Smegmamorpha - microbiology Spleen statistical analysis Synbranchiformes tissues TLR7 protein TLR7 subfamily TLR9 protein Toll-like receptor 7 Toll-Like Receptor 7 - genetics Toll-Like Receptor 7 - immunology Toll-like receptor 8 Toll-like receptor 9 Toll-like receptors |
| Title | Characterization, evolution, and expression analysis of TLR7 gene subfamily members in Mastacembelus armatus (Synbranchiformes: Mastacembelidae) |
| URI | https://dx.doi.org/10.1016/j.dci.2019.02.002 https://www.ncbi.nlm.nih.gov/pubmed/30742850 https://www.proquest.com/docview/2204765210 https://www.proquest.com/docview/2183181779 https://www.proquest.com/docview/2221016204 |
| Volume | 95 |
| WOSCitedRecordID | wos000462107900009&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVESC databaseName: Elsevier SD Freedom Collection Journals 2021 customDbUrl: eissn: 1879-0089 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0000810 issn: 0145-305X databaseCode: AIEXJ dateStart: 19950101 isFulltext: true titleUrlDefault: https://www.sciencedirect.com providerName: Elsevier |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwtV3db9MwELdKB4gXBOOrMCYj8QBsQanzYZu3aRoaiE18DKniJUqci5apS8faVN1_wf_EP4YvcZysohN74CVqHceJc7_4Lpff3RHyMknCAIbD1FG-AMdXQ3ASLxCOl2hdGPNEGyVxVWyCHx6K0Uh-7vV-N7Ew8zEvCrFYyLP_KmrdpoWNobPXELcdVDfo31roeqvFrrf_JPhdm4K5jrDEmwhzc8qGrAkLQ4BFLnKbluTo01eORZVha1omxvdxClgzpKLNHsTallT4f1xOt9AZPisrr-23iyLBCh3HGOd1WtPsOp3zNLbJn4wh3CErmWwFqpOHPMeolUsO__3YsAMmRtUiiahiInzRAO80lRUukeSQt8dW_uAfx_lP29c4OjC2qiFkWd9n4OjladRdvGXQWX1NQRijx8VfNUTtrDh5m6ociX2yztjKWnXYUACWtKTlLja0uJNIDxHhEJHLoiqh6RrjgRR9srbzYW_0sTUIRJUUw15_83G9ohkuXccq82jV609lBh3dI3fN-wvdqXF3n_SgWCe36oqmF-vk9oHhajwgv5aBuE0tDLepljhtQUgbENJJRhGEFEFILQipASHNC3oJhNSAkL5ahuA7ugTA1w_J9_d7R7v7jqn_gQuHO3NirRxAJhAkcphiyHWIBj-ATFMepG7qQ6piyZRMYlemMsjCEIABgMtjJUToPSL9YlLAE0IFZJniwk-9xNMjKCEzxjMJAQsZxFwOiNvc9kiZ5PhYo2UcrRT3gLyxh5zVmWGu6uw3soyMaVubrJHG5VWHbTRyj8wSM40Yc30earPbHZAXdrfWCvipLy5gUuo-WlNr253jzFb2YQzPqkcbkMc1puxEPHSZicB9ep1JPiN32ud2g_Rn5yU8JzfVfJZPzzfJDT4Sm-bZ-AOP3fUl |
| linkProvider | Elsevier |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Characterization%2C+evolution%2C+and+expression+analysis+of+TLR7+gene+subfamily+members+in+Mastacembelus+armatus+%28Synbranchiformes%3A+Mastacembelidae%29&rft.jtitle=Developmental+and+comparative+immunology&rft.au=Han%2C+Chong&rft.au=Li%2C+Qiang&rft.au=Liu%2C+Jinmei&rft.au=Hao%2C+Zhiqiang&rft.date=2019-06-01&rft.issn=0145-305X&rft.volume=95&rft.spage=77&rft.epage=88&rft_id=info:doi/10.1016%2Fj.dci.2019.02.002&rft.externalDBID=n%2Fa&rft.externalDocID=10_1016_j_dci_2019_02_002 |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=0145-305X&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=0145-305X&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=0145-305X&client=summon |