Presynaptic α4β2 nicotinic acetylcholine receptors increase glutamate release and serotonin neuron excitability in the dorsal raphe nucleus

Several behavioral effects of nicotine are mediated by changes in serotonin (5-HT) release in brain areas that receive serotonergic afferents from the dorsal raphe nucleus (DRN). In vitro experiments have demonstrated that nicotine increases the firing activity in the majority of DRN 5-HT neurons an...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 32; no. 43; p. 15148
Main Authors:	Garduño, Julieta, Galindo-Charles, Luis, Jiménez-Rodríguez, Javier, Galarraga, Elvira, Tapia, Dagoberto, Mihailescu, Stefan, Hernandez-Lopez, Salvador
Format:	Journal Article
Language:	English
Published:	United States 24.10.2012
Subjects:	6-Cyano-7-nitroquinoxaline-2,3-dione - pharmacology Acetylcholine - pharmacology Aconitine - analogs & derivatives Aconitine - pharmacology Animals Animals, Newborn Atropine - pharmacology Bicuculline - pharmacology Cadmium Chloride - pharmacology Chelating Agents - pharmacology Cholinergic Agonists - pharmacology Dihydro-beta-Erythroidine - pharmacology Egtazic Acid - analogs & derivatives Egtazic Acid - pharmacology Electric Stimulation Enzyme Inhibitors - pharmacology Excitatory Amino Acid Antagonists - pharmacology Excitatory Postsynaptic Potentials - drug effects Excitatory Postsynaptic Potentials - physiology GABA Antagonists - pharmacology Glutamic Acid - physiology In Vitro Techniques Indoles - pharmacology Male Muscarinic Antagonists - pharmacology Nicotine - analogs & derivatives Nicotine - pharmacology Nicotinic Antagonists - pharmacology Patch-Clamp Techniques Physostigmine - pharmacology Presynaptic Terminals - drug effects Presynaptic Terminals - physiology Raphe Nuclei - cytology Rats Rats, Wistar Receptors, Nicotinic - physiology Ryanodine - pharmacology Serotonergic Neurons - cytology Serotonergic Neurons - physiology Serotonin - metabolism Sodium Channel Blockers - pharmacology Tetrodotoxin - pharmacology
ISSN:	1529-2401, 1529-2401
Online Access:	Get more information
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