Asymmetrically lesioned mesencephalon in healthy rodents: call for caution
Stereological counting of tyrosine-hydroxylase immunoreactive (TH-IR) neurons in the mesencephalon is a pivotal parameter in assessing the extent of lesioning in animal models of Parkinson's disease. We here show that the number of TH-IR neurons often appears abnormally decreased in healthy—com...
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| Vydané v: | Brain research Ročník 1022; číslo 1; s. 251 - 253 |
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| Hlavní autori: | , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Elsevier B.V
01.10.2004
Amsterdam Elsevier New York, NY |
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| Abstract | Stereological counting of tyrosine-hydroxylase immunoreactive (TH-IR) neurons in the mesencephalon is a pivotal parameter in assessing the extent of lesioning in animal models of Parkinson's disease. We here show that the number of TH-IR neurons often appears abnormally decreased in healthy—commercially available—mice and rats, although both the number of Nissl-stained cells and the striatal dopaminergic innervation are unaffected. This potential bias in assessing extent of neurotoxin-induced lesion and subsequent protection by pharmacological manipulation prompts us to call for caution in setting up experimental designs. |
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| AbstractList | Stereological counting of tyrosine-hydroxylase immunoreactive (TH-IR) neurons in the mesencephalon is a pivotal parameter in assessing the extent of lesioning in animal models of Parkinson's disease. We here show that the number of TH-IR neurons often appears abnormally decreased in healthy--commercially available--mice and rats, although both the number of Nissl-stained cells and the striatal dopaminergic innervation are unaffected. This potential bias in assessing extent of neurotoxin-induced lesion and subsequent protection by pharmacological manipulation prompts us to call for caution in setting up experimental designs. Stereological counting of tyrosine-hydroxylase immunoreactive (TH-IR) neurons in the mesencephalon is a pivotal parameter in assessing the extent of lesioning in animal models of Parkinson's disease. We here show that the number of TH-IR neurons often appears abnormally decreased in healthy--commercially available--mice and rats, although both the number of Nissl-stained cells and the striatal dopaminergic innervation are unaffected. This potential bias in assessing extent of neurotoxin-induced lesion and subsequent protection by pharmacological manipulation prompts us to call for caution in setting up experimental designs.Stereological counting of tyrosine-hydroxylase immunoreactive (TH-IR) neurons in the mesencephalon is a pivotal parameter in assessing the extent of lesioning in animal models of Parkinson's disease. We here show that the number of TH-IR neurons often appears abnormally decreased in healthy--commercially available--mice and rats, although both the number of Nissl-stained cells and the striatal dopaminergic innervation are unaffected. This potential bias in assessing extent of neurotoxin-induced lesion and subsequent protection by pharmacological manipulation prompts us to call for caution in setting up experimental designs. |
| Author | Dovero, Sandra Pioli, Elsa Y. Bioulac, Bernard H. Bezard, Erwan Gross, Christian E. |
| Author_xml | – sequence: 1 givenname: Elsa Y. surname: Pioli fullname: Pioli, Elsa Y. – sequence: 2 givenname: Sandra surname: Dovero fullname: Dovero, Sandra – sequence: 3 givenname: Bernard H. surname: Bioulac fullname: Bioulac, Bernard H. – sequence: 4 givenname: Christian E. surname: Gross fullname: Gross, Christian E. – sequence: 5 givenname: Erwan surname: Bezard fullname: Bezard, Erwan email: erwan.bezard@umr5543.u-bordeaux2.fr |
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| Cites_doi | 10.1046/j.1471-4159.2003.01600.x 10.1016/S0969-9961(03)00011-1 10.1002/(SICI)1096-9861(19960318)366:4<580::AID-CNE3>3.0.CO;2-0 10.1038/nn941 10.1046/j.1471-4159.2003.01533.x 10.1016/j.tips.2004.03.003 10.3109/01677068709167184 10.1515/REVNEURO.1998.9.2.71 10.1002/cne.903310302 10.1023/A:1010257808945 10.1007/BF01248996 10.1006/neur.1996.0041 |
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| Keywords | J: Disorders of the nervous system Neuroprotection Tyrosine hydroxylase Parkinson's disease Substantia nigra pars compacta Animal model Rat Central nervous system Parkinson disease Tyrosine 3-monooxygenase Encephalon Degenerative disease Nervous system diseases Enzyme Rodentia Midbrain Cerebral disorder Vertebrata Mammalia Locus niger Asymmetry Mouse Central nervous system disease Oxidoreductases Lesion Extrapyramidal syndrome |
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| References | Dawson, Dawson (bib2) 2002 German, Nelson, Liang, Speciale, Sinton, Sonsalla (bib5) 1996; 5 Gross, Ravenscroft, Dovero, Jaber, Bioulac, Bezard (bib6) 2003; 84 Zaborszky, Vadasz (bib12) 2001; 31 Meissner, Dovero, Bioulac, Gross, Bezard (bib8) 2003; 13 Meissner, Hill, Tison, Gross, Bezard (bib9) 2004; 25 German, Manaye (bib3) 1993; 331 Bezard, Imbert, Gross (bib1) 1998; 9 German, Schlusselberg, Woodward (bib4) 1983; 57 Oorschot (bib10) 1996; 366 Hoglinger, Feger, Prigent, Michel, Parain, Champy, Ruberg, Oertel, Hirsch (bib7) 2003; 84 Vadasz, Sziraki, Murthy, Vadasz, Badalamenti, Kobor, Lajtha (bib11) 1987; 4 German (10.1016/j.brainres.2004.07.014_bib3) 1993; 331 Gross (10.1016/j.brainres.2004.07.014_bib6) 2003; 84 Bezard (10.1016/j.brainres.2004.07.014_bib1) 1998; 9 Oorschot (10.1016/j.brainres.2004.07.014_bib10) 1996; 366 Meissner (10.1016/j.brainres.2004.07.014_bib8) 2003; 13 Vadasz (10.1016/j.brainres.2004.07.014_bib11) 1987; 4 Dawson (10.1016/j.brainres.2004.07.014_bib2) 2002 Zaborszky (10.1016/j.brainres.2004.07.014_bib12) 2001; 31 Meissner (10.1016/j.brainres.2004.07.014_bib9) 2004; 25 German (10.1016/j.brainres.2004.07.014_bib4) 1983; 57 Hoglinger (10.1016/j.brainres.2004.07.014_bib7) 2003; 84 German (10.1016/j.brainres.2004.07.014_bib5) 1996; 5 |
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| SubjectTerms | Animals Biological and medical sciences Cell Count - methods Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Disease Models, Animal Immunohistochemistry - methods Male Medical sciences Mesencephalon - injuries Mesencephalon - pathology Mice Mice, Inbred C57BL Neurology Neurons - metabolism Neuroprotection Parkinson Disease - metabolism Parkinson Disease - pathology Parkinson's disease Probability Rats Rats, Wistar Rodentia Substantia nigra pars compacta Tyrosine 3-Monooxygenase - metabolism Tyrosine hydroxylase |
| Title | Asymmetrically lesioned mesencephalon in healthy rodents: call for caution |
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