Nerve growth factor sensitizes adult sympathetic neurons to the proinflammatory peptide bradykinin

Levels of nerve growth factor (NGF) are elevated in inflamed tissues. In sensory neurons, increases in NGF augment neuronal sensitivity (sensitization) to noxious stimuli. Here, we hypothesized that NGF also sensitizes sympathetic neurons to proinflammatory stimuli. We cultured superior cervical gan...

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Bibliographic Details
Published in:	The Journal of neuroscience Vol. 34; no. 36; p. 11959
Main Authors:	Vivas, Oscar, Kruse, Martin, Hille, Bertil
Format:	Journal Article
Language:	English
Published:	United States 03.09.2014
Subjects:	Action Potentials Animals Bradykinin - pharmacology Calcium Channel Blockers - pharmacology Calcium Channels - metabolism Calcium Signaling Cells, Cultured Inflammation Mediators - pharmacology Large-Conductance Calcium-Activated Potassium Channels - antagonists & inhibitors Large-Conductance Calcium-Activated Potassium Channels - metabolism Male Nerve Growth Factor - pharmacology Neurons - drug effects Neurons - metabolism Neurons - physiology Nifedipine - pharmacology Paxillin - pharmacology Peptides - pharmacology Phosphatidylinositol 4,5-Diphosphate - metabolism Potassium Channel Blockers - pharmacology Rats Rats, Sprague-Dawley Receptor, trkA - metabolism Superior Cervical Ganglion - cytology Superior Cervical Ganglion - drug effects Superior Cervical Ganglion - metabolism Superior Cervical Ganglion - physiology BK channel nifedipine-sensitive calcium channel Maxi-K channel superior cervical ganglion neurons slo1 channel M-current
ISSN:	1529-2401, 1529-2401
Online Access:	Get more information
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