Inflammatory pathway interactions and cancer multidrug resistance regulation

Multidrug resistances against chemotherapeutics are among the major challenges related to cancer treatment. Recent studies have demonstrated that different conditions may tune the expression and activity of MDR transporters. For instance, inflammation occurs through a complex cytological process and...

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Published in:	Life sciences (1973) Vol. 235; p. 116825
Main Authors:	Mirzaei, Seyed Abbas, Dinmohammadi, Farideh, Alizadeh, Akram, Elahian, Fatemeh
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 15.10.2019 Elsevier BV
Subjects:	anti-inflammatory activity Bioavailability Cancer Cancer therapies carcinogenesis Chemical reactions Chemotherapy Cytokine Cytokines Drug resistance drug therapy Glucocorticoids humans Inflammation Interleukin Interleukins mortality Multidrug resistance multiple drug resistance neoplasm cells neoplasms nonsteroidal anti-inflammatory agents Nonsteroidal anti-inflammatory drugs Organic chemistry Pharmacogenetics pharmacogenomics Pharmacokinetics Pharmacology Post-transcription Prostaglandins Reagents Regulatory mechanisms (biology) tissues transcription (genetics) transporters Inflammation Interleukin Multidrug resistance Cytokine Cancer
ISSN:	0024-3205, 1879-0631, 1879-0631
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Abstract	Multidrug resistances against chemotherapeutics are among the major challenges related to cancer treatment. Recent studies have demonstrated that different conditions may tune the expression and activity of MDR transporters. For instance, inflammation occurs through a complex cytological process and chemical reactions in the most tumor microenvironment; it can play a critical role in cancer development and is capable of altering the expression and function of MDR transporters. Cytokines, interleukins, and prostaglandins are potent inflammatory mediators that can modulate the expression of MDRs at transcriptional and post-transcriptional levels in the most human cancer cells and tissues and potentially contribute to balance bioavailability of chemotherapeutic agents. Since cancer cases are usually accompanied by inflammatory responses, glucocorticoids and NSAIDs are the primary useful combination chemotherapies in a variety of cancer treatment protocols. In addition to the anti-inflammatory activities of these agents, they exert diverse modulatory effects on MDR-mediated drug resistance via specific mechanisms. Several factors, including cell and MDR-protein types, pharmacokinetics, and pharmacogenetics, mainly influence the regulatory mechanisms. Uncovering the networks between inflammation and multidrug resistance will be clinically helpful in the treatment of malignant cancers and decreasing the cancer mortality rates.
AbstractList	Multidrug resistances against chemotherapeutics are among the major challenges related to cancer treatment. Recent studies have demonstrated that different conditions may tune the expression and activity of MDR transporters. For instance, inflammation occurs through a complex cytological process and chemical reactions in the most tumor microenvironment; it can play a critical role in cancer development and is capable of altering the expression and function of MDR transporters. Cytokines, interleukins, and prostaglandins are potent inflammatory mediators that can modulate the expression of MDRs at transcriptional and post-transcriptional levels in the most human cancer cells and tissues and potentially contribute to balance bioavailability of chemotherapeutic agents. Since cancer cases are usually accompanied by inflammatory responses, glucocorticoids and NSAIDs are the primary useful combination chemotherapies in a variety of cancer treatment protocols. In addition to the anti-inflammatory activities of these agents, they exert diverse modulatory effects on MDR-mediated drug resistance via specific mechanisms. Several factors, including cell and MDR-protein types, pharmacokinetics, and pharmacogenetics, mainly influence the regulatory mechanisms. Uncovering the networks between inflammation and multidrug resistance will be clinically helpful in the treatment of malignant cancers and decreasing the cancer mortality rates. Multidrug resistances against chemotherapeutics are among the major challenges related to cancer treatment. Recent studies have demonstrated that different conditions may tune the expression and activity of MDR transporters. For instance, inflammation occurs through a complex cytological process and chemical reactions in the most tumor microenvironment; it can play a critical role in cancer development and is capable of altering the expression and function of MDR transporters. Cytokines, interleukins, and prostaglandins are potent inflammatory mediators that can modulate the expression of MDRs at transcriptional and post-transcriptional levels in the most human cancer cells and tissues and potentially contribute to balance bioavailability of chemotherapeutic agents. Since cancer cases are usually accompanied by inflammatory responses, glucocorticoids and NSAIDs are the primary useful combination chemotherapies in a variety of cancer treatment protocols. In addition to the anti-inflammatory activities of these agents, they exert diverse modulatory effects on MDR-mediated drug resistance via specific mechanisms. Several factors, including cell and MDR-protein types, pharmacokinetics, and pharmacogenetics, mainly influence the regulatory mechanisms. Uncovering the networks between inflammation and multidrug resistance will be clinically helpful in the treatment of malignant cancers and decreasing the cancer mortality rates.Multidrug resistances against chemotherapeutics are among the major challenges related to cancer treatment. Recent studies have demonstrated that different conditions may tune the expression and activity of MDR transporters. For instance, inflammation occurs through a complex cytological process and chemical reactions in the most tumor microenvironment; it can play a critical role in cancer development and is capable of altering the expression and function of MDR transporters. Cytokines, interleukins, and prostaglandins are potent inflammatory mediators that can modulate the expression of MDRs at transcriptional and post-transcriptional levels in the most human cancer cells and tissues and potentially contribute to balance bioavailability of chemotherapeutic agents. Since cancer cases are usually accompanied by inflammatory responses, glucocorticoids and NSAIDs are the primary useful combination chemotherapies in a variety of cancer treatment protocols. In addition to the anti-inflammatory activities of these agents, they exert diverse modulatory effects on MDR-mediated drug resistance via specific mechanisms. Several factors, including cell and MDR-protein types, pharmacokinetics, and pharmacogenetics, mainly influence the regulatory mechanisms. Uncovering the networks between inflammation and multidrug resistance will be clinically helpful in the treatment of malignant cancers and decreasing the cancer mortality rates.
ArticleNumber	116825
Author	Mirzaei, Seyed Abbas Dinmohammadi, Farideh Alizadeh, Akram Elahian, Fatemeh
Author_xml	– sequence: 1 givenname: Seyed Abbas surname: Mirzaei fullname: Mirzaei, Seyed Abbas organization: Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 2 givenname: Farideh surname: Dinmohammadi fullname: Dinmohammadi, Farideh organization: Department of Food and Drug Control, School of Pharmacy, Zanjan University of Medical Sciences, Zanjan, Iran – sequence: 3 givenname: Akram surname: Alizadeh fullname: Alizadeh, Akram organization: Department of Tissue Engineering, School of Advanced Technologies, Shahrekord University of Medical Sciences, Shahrekord, Iran – sequence: 4 givenname: Fatemeh surname: Elahian fullname: Elahian, Fatemeh email: elahian@skums.ac.ir organization: Cancer Research Center, Shahrekord University of Medical Sciences, Shahrekord, Iran
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/31494169$$D View this record in MEDLINE/PubMed
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Snippet	Multidrug resistances against chemotherapeutics are among the major challenges related to cancer treatment. Recent studies have demonstrated that different...
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SubjectTerms	anti-inflammatory activity Bioavailability Cancer Cancer therapies carcinogenesis Chemical reactions Chemotherapy Cytokine Cytokines Drug resistance drug therapy Glucocorticoids humans Inflammation Interleukin Interleukins mortality Multidrug resistance multiple drug resistance neoplasm cells neoplasms nonsteroidal anti-inflammatory agents Nonsteroidal anti-inflammatory drugs Organic chemistry Pharmacogenetics pharmacogenomics Pharmacokinetics Pharmacology Post-transcription Prostaglandins Reagents Regulatory mechanisms (biology) tissues transcription (genetics) transporters
Title	Inflammatory pathway interactions and cancer multidrug resistance regulation
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