The autophagic tumor stroma model of cancer or "battery-operated tumor growth" A simple solution to the autophagy paradox

The role of autophagy in tumorigenesis is controversial. Both autophagy inhibitors (chloroquine) and autophagy promoters (rapamycin) block tumorigenesis by unknown mechanism(s). This is called the "Autophagy Paradox". We have recently reported a simple solution to this paradox. We demonstr...

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Bibliographic Details
Published in:	Cell cycle (Georgetown, Tex.) Vol. 9; no. 21; pp. 4297 - 4306
Main Authors:	Martinez-Outschoorn, Ubaldo E., Whitaker-Menezes, Diana, Pavlides, Stephanos, Chiavarina, Barbara, Bonuccelli, Gloria, Trimmer, Casey, Tsirigos, Aristotelis, Migneco, Gemma, Witkiewicz, Agnieszka K., Balliet, Renee M., Mercier, Isabelle, Wang, Chengwang, Flomenberg, Neal, Howell, Anthony, Lin, Zhao, Caro, Jaime, Pestell, Richard G., Sotgia, Federica, Lisanti, Michael P
Format:	Journal Article
Language:	English
Published:	United States Taylor & Francis 01.11.2010 Landes Bioscience
Subjects:	Animals Autophagy - physiology Binding Biology Bioscience Calcium Cancer Caveolin 1 - genetics Caveolin 1 - metabolism Cell Cycle DNA Damage Genomic Instability Landes Mice MicroRNAs - metabolism Models, Biological Neoplasms - diagnosis Neoplasms - metabolism Neoplasms - therapy Organogenesis Prognosis Proteins Review Stromal Cells - metabolism
ISSN:	1538-4101, 1551-4005, 1551-4005
Online Access:	Get full text
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