Bioinformatic discovery of novel bioactive peptides

Short synthetic oligopeptides based on regions of human proteins that encompass functional motifs are versatile reagents for understanding protein signaling and interactions. They can either mimic or inhibit the parent protein's activity 1 , 2 , 3 , 4 and have been used in drug development 5 ....

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Veröffentlicht in:	Nature chemical biology Jg. 3; H. 2; S. 108 - 112
Hauptverfasser:	Edwards, Richard J, Moran, Niamh, Devocelle, Marc, Kiernan, Aoife, Meade, Gerardene, Signac, William, Foy, Martina, Park, Stephen D E, Dunne, Eimear, Kenny, Dermot, Shields, Denis C
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Nature Publishing Group US 01.02.2007 Nature Publishing Group
Schlagworte:	Adenosine Diphosphate - secretion Adhesion Amino Acid Sequence Antigens, Differentiation, T-Lymphocyte - genetics Antigens, Differentiation, T-Lymphocyte - metabolism Biochemical Engineering Biochemistry Bioinformatics Biology Bioorganic Chemistry Blood Platelets - drug effects Blood Platelets - metabolism Cell Adhesion Molecules - genetics Cell Biology Chemistry Chemistry and Materials Science Chemistry/Food Science Cluster Analysis Computational Biology - methods Drug Evaluation, Preclinical Humans letter Membrane Proteins - genetics Molecular Mimicry - genetics Oligopeptides - chemistry Oligopeptides - genetics Oligopeptides - pharmacology Palmitic Acid - chemistry Peptide Fragments - genetics Peptide Fragments - pharmacology Peptides Platelet Activation - drug effects Platelet Aggregation - drug effects Platelet Aggregation Inhibitors - chemistry Platelet Aggregation Inhibitors - pharmacology Platelet Glycoprotein GPIIb-IIIa Complex - metabolism Proteins Reagents Signal transduction
ISSN:	1552-4450, 1552-4469
Online-Zugang:	Volltext
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