Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression

RBPs (RNA-binding proteins) have been described to be expressed and regulated in various organs including the heart. Little is known about the role of RBPs in heart failure induced by the chemotherapy drug doxorubicin and their interaction with circular RNAs. We aimed to identify key RBPs involved i...

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Vydané v:	Circulation research Ročník 122; číslo 2; s. 246
Hlavní autori:	Gupta, Shashi Kumar, Garg, Ankita, Bär, Christian, Chatterjee, Shambhabi, Foinquinos, Ariana, Milting, Hendrik, Streckfuß-Bömeke, Katrin, Fiedler, Jan, Thum, Thomas
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 19.01.2018
Predmet:	Animals Antibiotics, Antineoplastic - toxicity Cardiotoxicity - genetics Cardiotoxicity - metabolism Doxorubicin - toxicity Gene Expression Mice Mice, Inbred C57BL Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Random Allocation RNA - biosynthesis RNA - genetics RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics heart failure RNA-binding protein cardiotoxicity noncoding RNA doxorubicin
ISSN:	1524-4571, 1524-4571
On-line prístup:	Zistit podrobnosti o prístupe
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