Quaking Inhibits Doxorubicin-Mediated Cardiotoxicity Through Regulation of Cardiac Circular RNA Expression

RBPs (RNA-binding proteins) have been described to be expressed and regulated in various organs including the heart. Little is known about the role of RBPs in heart failure induced by the chemotherapy drug doxorubicin and their interaction with circular RNAs. We aimed to identify key RBPs involved i...

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Veröffentlicht in:	Circulation research Jg. 122; H. 2; S. 246
Hauptverfasser:	Gupta, Shashi Kumar, Garg, Ankita, Bär, Christian, Chatterjee, Shambhabi, Foinquinos, Ariana, Milting, Hendrik, Streckfuß-Bömeke, Katrin, Fiedler, Jan, Thum, Thomas
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 19.01.2018
Schlagworte:	Animals Antibiotics, Antineoplastic - toxicity Cardiotoxicity - genetics Cardiotoxicity - metabolism Doxorubicin - toxicity Gene Expression Mice Mice, Inbred C57BL Myocytes, Cardiac - drug effects Myocytes, Cardiac - metabolism Random Allocation RNA - biosynthesis RNA - genetics RNA-Binding Proteins - biosynthesis RNA-Binding Proteins - genetics heart failure RNA-binding protein cardiotoxicity noncoding RNA doxorubicin
ISSN:	1524-4571, 1524-4571
Online-Zugang:	Weitere Angaben
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