Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics
Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for...
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| Veröffentlicht in: | Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 43; S. 21427 |
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| Format: | Journal Article |
| Sprache: | Englisch |
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22.10.2019
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| ISSN: | 1091-6490, 1091-6490 |
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| Abstract | Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for physical tethers that connect external equipment to rigid probes inserted into delicate regions of the brain. The results can lead to tissue damage and alterations in behavioral tasks and natural movements, with additional difficulties in use for studies that involve social interactions and/or motions in complex 3-dimensional environments. These disadvantages are particularly pronounced in research that demands combined optogenetic and pharmacological functions in a single experiment. Here, we present a lightweight, wireless, battery-free injectable microsystem that combines soft microfluidic and microscale inorganic light-emitting diode probes for programmable pharmacology and optogenetics, designed to offer the features of drug refillability and adjustable flow rates, together with programmable control over the temporal profiles. The technology has potential for large-scale manufacturing and broad distribution to the neuroscience community, with capabilities in targeting specific neuronal populations in freely moving animals. In addition, the same platform can easily be adapted for a wide range of other types of passive or active electronic functions, including electrical stimulation. |
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| AbstractList | Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for physical tethers that connect external equipment to rigid probes inserted into delicate regions of the brain. The results can lead to tissue damage and alterations in behavioral tasks and natural movements, with additional difficulties in use for studies that involve social interactions and/or motions in complex 3-dimensional environments. These disadvantages are particularly pronounced in research that demands combined optogenetic and pharmacological functions in a single experiment. Here, we present a lightweight, wireless, battery-free injectable microsystem that combines soft microfluidic and microscale inorganic light-emitting diode probes for programmable pharmacology and optogenetics, designed to offer the features of drug refillability and adjustable flow rates, together with programmable control over the temporal profiles. The technology has potential for large-scale manufacturing and broad distribution to the neuroscience community, with capabilities in targeting specific neuronal populations in freely moving animals. In addition, the same platform can easily be adapted for a wide range of other types of passive or active electronic functions, including electrical stimulation. Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for physical tethers that connect external equipment to rigid probes inserted into delicate regions of the brain. The results can lead to tissue damage and alterations in behavioral tasks and natural movements, with additional difficulties in use for studies that involve social interactions and/or motions in complex 3-dimensional environments. These disadvantages are particularly pronounced in research that demands combined optogenetic and pharmacological functions in a single experiment. Here, we present a lightweight, wireless, battery-free injectable microsystem that combines soft microfluidic and microscale inorganic light-emitting diode probes for programmable pharmacology and optogenetics, designed to offer the features of drug refillability and adjustable flow rates, together with programmable control over the temporal profiles. The technology has potential for large-scale manufacturing and broad distribution to the neuroscience community, with capabilities in targeting specific neuronal populations in freely moving animals. In addition, the same platform can easily be adapted for a wide range of other types of passive or active electronic functions, including electrical stimulation.Pharmacology and optogenetics are widely used in neuroscience research to study the central and peripheral nervous systems. While both approaches allow for sophisticated studies of neural circuitry, continued advances are, in part, hampered by technology limitations associated with requirements for physical tethers that connect external equipment to rigid probes inserted into delicate regions of the brain. The results can lead to tissue damage and alterations in behavioral tasks and natural movements, with additional difficulties in use for studies that involve social interactions and/or motions in complex 3-dimensional environments. These disadvantages are particularly pronounced in research that demands combined optogenetic and pharmacological functions in a single experiment. Here, we present a lightweight, wireless, battery-free injectable microsystem that combines soft microfluidic and microscale inorganic light-emitting diode probes for programmable pharmacology and optogenetics, designed to offer the features of drug refillability and adjustable flow rates, together with programmable control over the temporal profiles. The technology has potential for large-scale manufacturing and broad distribution to the neuroscience community, with capabilities in targeting specific neuronal populations in freely moving animals. In addition, the same platform can easily be adapted for a wide range of other types of passive or active electronic functions, including electrical stimulation. |
| Author | Hang, Tao Ostojich, Diana Guo, Hexia Qu, Subing Ausra, Jokubas Castro, Daniel C Zhang, Yi Wu, Yixin Banks, Anthony Weng, Zhengyan Han, Yuan Gutruf, Philipp Wu, Guangfu Peng, Dongsheng Radulovic, Jelena Xue, Yeguang Sun, Rujie Leshock, John P Shen, Wen Wang, Binbin Xie, Yiwen Vázquez-Guardado, Abraham Yu, Yongjoon Huang, Yonggang Bruchas, Michael R Rogers, John A Wang, Xueju Li, Rui Su, Chun-Ju Xie, Zhaoqian |
| Author_xml | – sequence: 1 givenname: Yi surname: Zhang fullname: Zhang, Yi organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 2 givenname: Daniel C surname: Castro fullname: Castro, Daniel C organization: Department of Anesthesiology and Pain Medicine, University of Washington, Seattle, WA 98195 – sequence: 3 givenname: Yuan surname: Han fullname: Han, Yuan organization: Jiangsu Province Key Laboratory of Anesthesiology, Xuzhou Medical University, 221004 Xuzhou, China – sequence: 4 givenname: Yixin surname: Wu fullname: Wu, Yixin organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 5 givenname: Hexia surname: Guo fullname: Guo, Hexia organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 6 givenname: Zhengyan surname: Weng fullname: Weng, Zhengyan organization: Department of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211 – sequence: 7 givenname: Yeguang orcidid: 0000-0002-1968-5092 surname: Xue fullname: Xue, Yeguang organization: Department of Mechanical Engineering, Northwestern University, Evanston, IL 60208 – sequence: 8 givenname: Jokubas surname: Ausra fullname: Ausra, Jokubas organization: Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721 – sequence: 9 givenname: Xueju surname: Wang fullname: Wang, Xueju organization: Department of Mechanical and Aerospace Engineering, University of Missouri, Columbia, MO 65211 – sequence: 10 givenname: Rui surname: Li fullname: Li, Rui organization: International Research Center for Computational Mechanics, Dalian University of Technology, 116024 Dalian, China – sequence: 11 givenname: Guangfu surname: Wu fullname: Wu, Guangfu organization: Department of Biomedical, Biological, and Chemical Engineering, University of Missouri, Columbia, MO 65211 – sequence: 12 givenname: Abraham surname: Vázquez-Guardado fullname: Vázquez-Guardado, Abraham organization: Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208 – sequence: 13 givenname: Yiwen surname: Xie fullname: Xie, Yiwen organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 14 givenname: Zhaoqian surname: Xie fullname: Xie, Zhaoqian organization: State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of Technology, 116024 Dalian, China – sequence: 15 givenname: Diana surname: Ostojich fullname: Ostojich, Diana organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 16 givenname: Dongsheng surname: Peng fullname: Peng, Dongsheng organization: College of Optoelectronic Engineering, Shenzhen University, 518060 Shenzhen, China – sequence: 17 givenname: Rujie surname: Sun fullname: Sun, Rujie organization: Bristol Composites Institute, University of Bristol, BS8 1TR Bristol, United Kingdom – sequence: 18 givenname: Binbin surname: Wang fullname: Wang, Binbin organization: Department of Civil and Environmental Engineering, University of Missouri, Columbia, MO 65211 – sequence: 19 givenname: Yongjoon surname: Yu fullname: Yu, Yongjoon organization: NeuroLux, Inc., Evanston, IL 60201 – sequence: 20 givenname: John P surname: Leshock fullname: Leshock, John P organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 21 givenname: Subing surname: Qu fullname: Qu, Subing organization: Department of Materials Science and Engineering, Materials Research Laboratory, University of Illinois at Urbana-Champaign, Urbana, IL 61801 – sequence: 22 givenname: Chun-Ju surname: Su fullname: Su, Chun-Ju organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 23 givenname: Wen surname: Shen fullname: Shen, Wen organization: Department of Mechanical and Aerospace Engineering, University of Texas at Arlington, Arlington, TX 76019 – sequence: 24 givenname: Tao surname: Hang fullname: Hang, Tao organization: School of Materials Science and Engineering, Shanghai Jiao Tong University, 200240 Shanghai, China – sequence: 25 givenname: Anthony surname: Banks fullname: Banks, Anthony organization: Department of Materials Science and Engineering, Northwestern University, Evanston, IL 60208 – sequence: 26 givenname: Yonggang surname: Huang fullname: Huang, Yonggang organization: Center for Bio-Integrated Electronics, Northwestern University, Evanston, IL 60208 – sequence: 27 givenname: Jelena surname: Radulovic fullname: Radulovic, Jelena organization: Department of Psychiatry and Behavioral Sciences, Northwestern University, Chicago, IL 60611 – sequence: 28 givenname: Philipp surname: Gutruf fullname: Gutruf, Philipp email: pgutruf@email.arizona.edu, mbruchas@uw.edu, jrogers@northwestern.edu organization: Biomedical Engineering, College of Engineering, The University of Arizona, Tucson, AZ 85721; pgutruf@email.arizona.edu mbruchas@uw.edu jrogers@northwestern.edu – sequence: 29 givenname: Michael R surname: Bruchas fullname: Bruchas, Michael R email: pgutruf@email.arizona.edu, mbruchas@uw.edu, jrogers@northwestern.edu organization: Department of Pharmacology, University of Washington, Seattle, WA 98195 – sequence: 30 givenname: John A surname: Rogers fullname: Rogers, John A email: pgutruf@email.arizona.edu, mbruchas@uw.edu, jrogers@northwestern.edu organization: Department of Neurological Surgery, Feinberg School of Medicine, Northwestern University, Chicago, IL 60611 |
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| SubjectTerms | Animals Brain - metabolism Brain Chemistry Channelrhodopsins - metabolism Electric Stimulation Female Male Mice Mice, Inbred C57BL Optogenetics - instrumentation Optogenetics - methods Pharmacology - instrumentation Pharmacology - methods Prostheses and Implants Wireless Technology - instrumentation |
| Title | Battery-free, lightweight, injectable microsystem for in vivo wireless pharmacology and optogenetics |
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