Hepatitis B virus X protein recruits methyltransferases to affect cotranscriptional N6-methyladenosine modification of viral/host RNAs

Chronic hepatitis B virus (HBV) infections are one of the leading causes of cirrhosis and hepatocellular carcinoma. N6-methyladenosine (m A) modification of cellular and viral RNAs is the most prevalent internal modification that occurs cotranscriptionally. Previously, we reported the dual functiona...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 118; číslo 3
Hlavní autoři:	Kim, Geon-Woo, Siddiqui, Aleem
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 19.01.2021
Témata:	Adenosine - analogs & derivatives Adenosine - genetics Hep G2 Cells Hepatitis B virus - genetics Hepatitis B virus - pathogenicity Hepatitis B, Chronic - genetics Hepatitis B, Chronic - virology Host-Pathogen Interactions - genetics Humans Methyltransferases - genetics PTEN Phosphohydrolase - genetics RNA Processing, Post-Transcriptional - genetics RNA, Viral - genetics Trans-Activators - genetics Viral Regulatory and Accessory Proteins - genetics Virus Replication - genetics cotranscriptional modification hepatitis B virus X protein METTL3/14 N6-methyladenosine modification hepatitis B virus
ISSN:	1091-6490, 1091-6490
On-line přístup:	Zjistit podrobnosti o přístupu
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