High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment

Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despit...

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Bibliographic Details
Published in:	Journal of virology Vol. 83; no. 21; p. 11407
Main Authors:	Gonzalez, Veronica D, Falconer, Karolin, Blom, Kim G, Reichard, Olle, Mørn, Birgitte, Laursen, Alex Lund, Weis, Nina, Alaeus, Annette, Sandberg, Johan K
Format:	Journal Article
Language:	English
Published:	United States 01.11.2009
Subjects:	ADP-ribosyl Cyclase 1 - immunology Adult Antiretroviral Therapy, Highly Active Antiviral Agents - therapeutic use Disease Progression Female Hepacivirus - immunology Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Humans Interferon-alpha - immunology Interferon-alpha - therapeutic use Lymphocyte Activation - immunology Male Middle Aged Ribavirin - therapeutic use T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology T-Lymphocytes - immunology T-Lymphocytes - virology Viral Load Young Adult
ISSN:	1098-5514, 1098-5514
Online Access:	Get more information
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