High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment
Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despit...
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| Published in: | Journal of virology Vol. 83; no. 21; p. 11407 |
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| Main Authors: | , , , , , , , , |
| Format: | Journal Article |
| Language: | English |
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United States
01.11.2009
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| ISSN: | 1098-5514, 1098-5514 |
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| Abstract | Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients. |
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| AbstractList | Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients.Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients. Chronic immune activation is a driver of human immunodeficiency virus type 1 (HIV-1) disease progression. Here, we describe that subjects with chronic hepatitis C virus (HCV)/HIV-1 coinfection display sharply elevated immune activation as determined by CD38 expression in T cells. This occurs, despite effective antiretroviral therapy, in both CD8 and CD4 T cells and is more pronounced than in the appropriate monoinfected control groups. Interestingly, the suppression of HCV by pegylated alpha interferon and ribavirin treatment reduces activation. High HCV loads and elevated levels of chronic immune activation may contribute to the high rates of viral disease progression observed in HCV/HIV-1-coinfected patients. |
| Author | Weis, Nina Mørn, Birgitte Laursen, Alex Lund Falconer, Karolin Reichard, Olle Alaeus, Annette Blom, Kim G Sandberg, Johan K Gonzalez, Veronica D |
| Author_xml | – sequence: 1 givenname: Veronica D surname: Gonzalez fullname: Gonzalez, Veronica D organization: Center for Infectious Medicine, Department of Medicine, Karolinska Institutet, Karolinska University Hospital Huddinge, 14186 Stockholm, Sweden – sequence: 2 givenname: Karolin surname: Falconer fullname: Falconer, Karolin – sequence: 3 givenname: Kim G surname: Blom fullname: Blom, Kim G – sequence: 4 givenname: Olle surname: Reichard fullname: Reichard, Olle – sequence: 5 givenname: Birgitte surname: Mørn fullname: Mørn, Birgitte – sequence: 6 givenname: Alex Lund surname: Laursen fullname: Laursen, Alex Lund – sequence: 7 givenname: Nina surname: Weis fullname: Weis, Nina – sequence: 8 givenname: Annette surname: Alaeus fullname: Alaeus, Annette – sequence: 9 givenname: Johan K surname: Sandberg fullname: Sandberg, Johan K |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/19710147$$D View this record in MEDLINE/PubMed |
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| SubjectTerms | ADP-ribosyl Cyclase 1 - immunology Adult Antiretroviral Therapy, Highly Active Antiviral Agents - therapeutic use Disease Progression Female Hepacivirus - immunology Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - immunology Hepatitis C, Chronic - virology HIV Infections - drug therapy HIV Infections - immunology HIV Infections - virology HIV-1 - immunology Humans Interferon-alpha - immunology Interferon-alpha - therapeutic use Lymphocyte Activation - immunology Male Middle Aged Ribavirin - therapeutic use T-Lymphocyte Subsets - immunology T-Lymphocyte Subsets - virology T-Lymphocytes - immunology T-Lymphocytes - virology Viral Load Young Adult |
| Title | High levels of chronic immune activation in the T-cell compartments of patients coinfected with hepatitis C virus and human immunodeficiency virus type 1 and on highly active antiretroviral therapy are reverted by alpha interferon and ribavirin treatment |
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