Unifying structural signature of eukaryotic α-helical host defense peptides

Diversity of α-helical host defense peptides (αHDPs) contributes to immunity against a broad spectrum of pathogens via multiple functions. Thus, resolving common structure-function relationships among αHDPs is inherently difficult, even for artificial-intelligence-based methods that seek multifactor...

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Veröffentlicht in:	Proceedings of the National Academy of Sciences - PNAS Jg. 116; H. 14; S. 6944
Hauptverfasser:	Yount, Nannette Y, Weaver, David C, Lee, Ernest Y, Lee, Michelle W, Wang, Huiyuan, Chan, Liana C, Wong, Gerard C L, Yeaman, Michael R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States 02.04.2019
Schlagworte:	Eukaryotic Cells Pattern Recognition, Automated Peptides - chemistry Peptides - genetics Protein Structure, Secondary Sequence Analysis, Protein antimicrobial amphipathic antiinfective bioinformatics host defense
ISSN:	1091-6490, 1091-6490
Online-Zugang:	Weitere Angaben
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