Within-Subject Comparison of [11C]-( + )-PHNO and [11C]raclopride Sensitivity to Acute Amphetamine Challenge in Healthy Humans

[11C]PHNO is a D2/D3 agonist positron emission tomography radiotracer, with higher in vivo affinity for D3 than for D2 receptors. As [11C]-( + )-PHNO is an agonist, its in vivo binding is expected to be more affected by acute fluctuations in synaptic dopamine than that of antagonist radiotracers suc...

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Vydáno v:	Journal of cerebral blood flow and metabolism Ročník 32; číslo 1; s. 127 - 136
Hlavní autoři:	Shotbolt, Paul, Tziortzi, Andri C, Searle, Graham E, Colasanti, Alessandro, van der Aart, Jasper, Abanades, Sergio, Plisson, Christophe, Miller, Sam R, Huiban, Mickael, Beaver, John D, Gunn, Roger N, Laruelle, Marc, Rabiner, Eugenii A
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	London, England SAGE Publications 01.01.2012 Nature Publishing Group Sage Publications Ltd
Témata:	Adult Amphetamine - blood Amphetamine - pharmacology Binding, Competitive Biological and medical sciences Brain - drug effects Brain - metabolism Development. Senescence. Regeneration. Transplantation Dopamine - metabolism Dopamine Agonists - pharmacokinetics Dopamine Antagonists - pharmacokinetics Dopamine D2 Receptor Antagonists Fundamental and applied biological sciences. Psychology Humans Ligands Male Medical sciences Middle Aged Neurology Original Oxazines - pharmacokinetics Positron-Emission Tomography - methods Protein Binding Raclopride - pharmacokinetics Radioligand Assay Radiopharmaceuticals - pharmacokinetics Receptors, Dopamine D2 - agonists Receptors, Dopamine D3 - agonists Receptors, Dopamine D3 - antagonists & inhibitors Sensitivity and Specificity Vascular diseases and vascular malformations of the nervous system Vertebrates: nervous system and sense organs brain imaging neurochemistry positron emission tomography dopamine receptor imaging Amphetamine derivatives Human Nervous system diseases Raclopride Dopamine CNS stimulant Neuroleptic Psychotropic Dopamine antagonist Catecholamine Cerebral disorder Encephalon D2 Dopamine receptor Central nervous system disease Neurotransmitter Amfetamine Positron emission tomography Comparative study Cerebrovascular disease Emission tomography
ISSN:	0271-678X, 1559-7016
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