A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum

SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons,...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS Jg. 119; H. 11; S. e2107339119
Hauptverfasser: Zhang, Yunjia, Li, Boxun, Cananzi, Sergio, Han, Chuanhui, Wang, Lei-Lei, Zou, Yuhua, Fu, Yang-Xin, Hon, Gary C, Zhang, Chun-Li
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.03.2022
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ISSN:1091-6490, 1091-6490
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Abstract SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.
AbstractList SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.
SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and reveal that a single factor can induce resident brain astrocytes to become induced neural progenitor cells (iNPCs), which then generate neurons, astrocytes, and oligodendrocytes. Such a conclusion is supported by single-cell RNA sequencing and multiple lineage-tracing experiments. Our discovery of iNPCs is fundamentally important for regenerative medicine since neural injuries or degeneration often lead to loss/dysfunction of all three neural lineages. Our findings also provide insights into cell plasticity in the adult mammalian brain, which has largely lost the regenerative capacity.
Author Zou, Yuhua
Fu, Yang-Xin
Zhang, Chun-Li
Cananzi, Sergio
Zhang, Yunjia
Han, Chuanhui
Li, Boxun
Wang, Lei-Lei
Hon, Gary C
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  orcidid: 0000-0002-4516-4418
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  fullname: Li, Boxun
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  fullname: Han, Chuanhui
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induced neural progenitor cells
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astrocytes
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Snippet SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and...
SignificanceOutside the neurogenic niches, the adult brain lacks multipotent progenitor cells. In this study, we performed a series of in vivo screens and...
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SubjectTerms Animals
Astrocytes - cytology
Astrocytes - metabolism
Basic Helix-Loop-Helix Transcription Factors - genetics
Cell Differentiation - genetics
Cell Lineage - genetics
Cellular Reprogramming - genetics
Corpus Striatum - cytology
Corpus Striatum - metabolism
Fluorescent Antibody Technique
GABAergic Neurons - cytology
GABAergic Neurons - metabolism
Gene Expression
Gene Expression Profiling
Gene Expression Regulation, Developmental
Gene Regulatory Networks
Genes, Reporter
Homeodomain Proteins - genetics
Homeodomain Proteins - metabolism
Mice
Multipotent Stem Cells - cytology
Multipotent Stem Cells - metabolism
Neural Stem Cells - cytology
Neural Stem Cells - metabolism
Neurogenesis
Receptors, Notch - metabolism
Repressor Proteins - genetics
Repressor Proteins - metabolism
RNA-Seq
Signal Transduction
Transcription Factors - genetics
Transcription Factors - metabolism
Tumor Suppressor Proteins - genetics
Tumor Suppressor Proteins - metabolism
Title A single factor elicits multilineage reprogramming of astrocytes in the adult mouse striatum
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