A tryptophan metabolite of the skin microbiota attenuates inflammation in patients with atopic dermatitis through the aryl hydrocarbon receptor

Previous studies have revealed significant alterations in the skin microbiota of patients with atopic dermatitis (AD) not only in diversity and composition but also in function, and the tryptophan (Trp) metabolic pathway is attenuated in the skin microbiota of patients with AD. We sought to assess T...

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Bibliographic Details
Published in:	Journal of allergy and clinical immunology Vol. 143; no. 6; pp. 2108 - 2119.e12
Main Authors:	Yu, Jinlei, Luo, Yang, Zhu, Zhenlai, Zhou, Yufeng, Sun, Licheng, Gao, Jixin, Sun, Jinlv, Wang, Gang, Yao, Xu, Li, Wei
Format:	Journal Article
Language:	English
Published:	United States Elsevier Inc 01.06.2019 Elsevier Limited
Subjects:	Animals aryl hydrocarbon receptor Atopic dermatitis Calcitriol - analogs & derivatives Calcitriol - immunology Cells, Cultured Cytokines - metabolism Dermatitis Dermatitis, Atopic - drug therapy Disease Models, Animal Eczema Homeostasis Humans Hydrocarbons indole-3-aldehyde Indoles Indoles - therapeutic use Inflammation Keratinocytes Keratinocytes - physiology Ligands Liquid chromatography Mass spectroscopy Metabolic pathways Metabolism Metabolites Mice Mice, Inbred BALB C Mice, Inbred C57BL Mice, Knockout Microbiota Microbiota - immunology Receptors, Aryl Hydrocarbon - genetics Receptors, Aryl Hydrocarbon - metabolism Skin Skin - metabolism Skin - microbiology Skin diseases Thymic stromal lymphopoietin Thymus Tryptophan Tryptophan - metabolism Up-Regulation microbiota DMSO skin FACS aryl hydrocarbon receptor CHS LC-MS/MS Trp Atopic dermatitis tryptophan KYN AD TSLP AhRE IAA AhR siRNA 5-HTP IMQ metabolites SCFA IAId thymic stromal lymphopoietin indole-3-aldehyde CYP1A1 OXA
ISSN:	0091-6749, 1097-6825, 1097-6825
Online Access:	Get full text
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