Dolutegravir as First- or Second-Line Treatment for HIV-1 Infection in Children

In an open-label, randomized, noninferiority trial, dolutegravir-based antiretroviral therapy was compared with standard care in children and adolescents starting first- or second-line therapy for HIV type 1 infection. Dolutegravir-based ART was superior to standard-care ART.

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Bibliographic Details
Published in:	The New England journal of medicine Vol. 385; no. 27; pp. 2531 - 2543
Main Authors:	Turkova, Anna, White, Ellen, Mujuru, Hilda A, Kekitiinwa, Adeodata R, Kityo, Cissy M, Violari, Avy, Lugemwa, Abbas, Cressey, Tim R, Musoke, Philippa, Variava, Ebrahim, Cotton, Mark F, Archary, Moherndran, Puthanakit, Thanyawee, Behuhuma, Osee, Kobbe, Robin, Welch, Steven B, Bwakura-Dangarembizi, Mutsa, Amuge, Pauline, Kaudha, Elizabeth, Barlow-Mosha, Linda, Makumbi, Shafic, Ramsagar, Nastassja, Ngampiyaskul, Chaiwat, Musoro, Godfrey, Atwine, Lorna, Liberty, Afaaf, Musiime, Victor, Bbuye, Dickson, Ahimbisibwe, Grace M, Chalermpantmetagul, Suwalai, Ali, Shabinah, Sarfati, Tatiana, Wynne, Ben, Shakeshaft, Clare, Colbers, Angela, Klein, Nigel, Bernays, Sarah, Saïdi, Yacine, Coelho, Alexandra, Grossele, Tiziana, Compagnucci, Alexandra, Giaquinto, Carlo, Rojo, Pablo, Ford, Deborah, Gibb, Diana M
Format:	Journal Article
Language:	English
Published:	United States Massachusetts Medical Society 30.12.2021
Subjects:	Acquired immune deficiency syndrome Administration, Oral Adolescence Adolescent Adolescents Adverse events AIDS Alkynes - therapeutic use Anti-Retroviral Agents - adverse effects Anti-Retroviral Agents - therapeutic use Antiretroviral drugs Antiretroviral therapy Benzoxazines - therapeutic use Caregivers Child Child, Preschool Children Cholesterol - blood Cyclopropanes - therapeutic use Drug Therapy, Combination Efavirenz FDA approval Female Global Health Heterocyclic Compounds, 3-Ring - administration & dosage Heterocyclic Compounds, 3-Ring - adverse effects Heterocyclic Compounds, 3-Ring - therapeutic use HIV HIV Infections - drug therapy HIV Infections - virology HIV Integrase Inhibitors - administration & dosage HIV Integrase Inhibitors - adverse effects HIV Integrase Inhibitors - therapeutic use HIV Protease Inhibitors - therapeutic use HIV-1 - isolation & purification Human immunodeficiency virus Humans Immune system Infections Infectious Disease Integrase Life Sciences Male Mutation Oxazines - administration & dosage Oxazines - adverse effects Oxazines - therapeutic use Pediatrics Pediatrics General Piperazines - administration & dosage Piperazines - adverse effects Piperazines - therapeutic use Proteinase inhibitors Pyridones - administration & dosage Pyridones - adverse effects Pyridones - therapeutic use Santé publique et épidémiologie Teenagers Viral Load - drug effects
ISSN:	0028-4793, 1533-4406, 1533-4406
Online Access:	Get full text
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