Normal values for calprotectin in stool samples of infants from the population-based longitudinal born into life study

Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a turbidimetric immunoassay in a cohort of Swedish children. The advantage of the method is tha...

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Published in:Scandinavian journal of clinical and laboratory investigation Vol. 78; no. 1-2; pp. 120 - 124
Main Authors: Peura, Sari, Fall, Tove, Almqvist, Catarina, Andolf, Ellika, Hedman, Anna, Pershagen, Göran, Helmersson-Karlqvist, Johanna, Larsson, Anders
Format: Journal Article
Language:English
Published: England Taylor & Francis 01.01.2018
Subjects:
abdominal pain
Calprotectin
inflammatory bowel disease
normal values
Reumatologi och inflammation
Rheumatology and Autoimmunity
turbidimetric immunoassay
normal values
abdominal pain
Calprotectin
turbidimetric immunoassay
inflammatory bowel disease
ISSN:0036-5513, 1502-7686, 1502-7686
Online Access:Get full text
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Summary:Faecal calprotectin is a protein used as a diagnostic marker for inflammatory bowel diseases. We determined upper limits for normal calprotectin values for neonatal, 6, 12 and 24 months old children using a turbidimetric immunoassay in a cohort of Swedish children. The advantage of the method is that opposite to previously used enzyme-linked immunosorbent assay (ELISA) method, it enables measuring single samples, and thus, shortens the analysis time significantly. There were 72 samples (41.7% female) collected neonatally, 63 samples (34.9% female) at 6 months, 60 samples (40.0% female) at 12 months and 51 samples (43.1% female) at 24 months. The upper limits for normal values were 233, 615, 136 and 57 µg mg −1 for infants aged 0, 6, 12 and 24 months, respectively.
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ISSN:0036-5513
1502-7686
1502-7686
DOI:10.1080/00365513.2017.1420216