Oncogenic role of PDK4 in human colon cancer cells

Background: Cancer cells maintain high rates of glycolysis. Pyruvate dehydrogenase kinases (PDK) contribute to this phenomenon, which favours apoptosis resistance and cellular transformation. We previously reported upregulation of PDK4 in normal mucosa of colorectal cancer (CRC) patients compared wi...

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Veröffentlicht in:	British journal of cancer Jg. 116; H. 7; S. 930 - 936
Hauptverfasser:	Leclerc, D, Pham, D N T, Lévesque, N, Truongcao, M, Foulkes, W D, Sapienza, C, Rozen, R
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 28.03.2017 Nature Publishing Group
Schlagworte:	631/67/2327 692/53/2421 Animals Apoptosis Biobanks Biomarkers, Tumor - genetics Biomarkers, Tumor - metabolism Biomedical and Life Sciences Biomedicine Cancer Research Carcinogenesis Case-Control Studies Cell Movement Cell Proliferation Colonic Neoplasms - genetics Colonic Neoplasms - metabolism Colonic Neoplasms - pathology Colorectal cancer Dehydrogenases DNA Methylation Drug Resistance Epidemiology Female Follow-Up Studies Gene Expression Regulation, Enzymologic Glucose Hospitals Human subjects Humans Immunoenzyme Techniques Kinases Male Medical research Metabolism Mice Middle Aged Molecular Diagnostics Molecular Medicine Neoplasm Staging Oncology Phosphorylation Prognosis Protein-Serine-Threonine Kinases - antagonists & inhibitors Protein-Serine-Threonine Kinases - genetics Protein-Serine-Threonine Kinases - metabolism RNA, Small Interfering - genetics Tumor Cells, Cultured Canada United States > US Montreal Quebec Canada hypoxia cancer detection RNAi cancer target methylation glycolysis pyrosequencing
ISSN:	0007-0920, 1532-1827, 1532-1827
Online-Zugang:	Volltext
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