Clinical presentation of celiac disease in the pediatric population

Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye, and barley) in genetically susceptible individuals. CD is associated with HLA molecules DQ2 (90%-95%) and DQ8 (5%-10%), and in the continued presence of gluten the dise...

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Vydáno v:Gastroenterology (New York, N.Y. 1943) Ročník 128; číslo 4 Suppl 1; s. S68
Hlavní autor: Fasano, Alessio
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 01.04.2005
Témata:
Adolescent
Age of Onset
Anorexia - etiology
Autoimmune Diseases
Celiac Disease - complications
Celiac Disease - diagnosis
Celiac Disease - pathology
Child
Child Development
Child, Preschool
Diarrhea - etiology
Female
Genetic Predisposition to Disease
Glutens - metabolism
Humans
Infant
Infant, Newborn
Male
Risk Factors
Severity of Illness Index
ISSN:0016-5085
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Shrnutí:Celiac disease (CD) is an immune-mediated enteropathy triggered by the ingestion of gluten-containing grains (including wheat, rye, and barley) in genetically susceptible individuals. CD is associated with HLA molecules DQ2 (90%-95%) and DQ8 (5%-10%), and in the continued presence of gluten the disease is self-perpetuating. CD is one of the most common lifelong disorders worldwide and is characterized by a variety of clinical presentations. These include the typical malabsorption syndrome (classic symptoms) and a spectrum of symptoms potentially affecting any organ or body system (nonclassic symptoms). Because CD often is atypical or even clinically silent, many cases go undiagnosed and are exposed to the risk of long-term complications. There is growing interest in the social aspects of CD because the burden of illness related to this condition is doubtless higher than previously thought.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
ObjectType-Review-3
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ISSN:0016-5085
DOI:10.1053/j.gastro.2005.02.015