A single oncogenic enhancer rearrangement causes concomitant EVI1 and GATA2 deregulation in leukemia

Chromosomal rearrangements without gene fusions have been implicated in leukemogenesis by causing deregulation of proto-oncogenes via relocation of cryptic regulatory DNA elements. AML with inv(3)/t(3;3) is associated with aberrant expression of the stem-cell regulator EVI1. Applying functional geno...

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Bibliographic Details
Published in:	Cell Vol. 157; no. 2; p. 369
Main Authors:	Gröschel, Stefan, Sanders, Mathijs A, Hoogenboezem, Remco, de Wit, Elzo, Bouwman, Britta A M, Erpelinck, Claudia, van der Velden, Vincent H J, Havermans, Marije, Avellino, Roberto, van Lom, Kirsten, Rombouts, Elwin J, van Duin, Mark, Döhner, Konstanze, Beverloo, H Berna, Bradner, James E, Döhner, Hartmut, Löwenberg, Bob, Valk, Peter J M, Bindels, Eric M J, de Laat, Wouter, Delwel, Ruud
Format:	Journal Article
Language:	English
Published:	United States 10.04.2014
Subjects:	Cell Line, Tumor Chromosome Inversion Chromosomes, Human, Pair 3 DNA-Binding Proteins - genetics Enhancer Elements, Genetic GATA2 Transcription Factor - genetics Gene Expression Regulation, Neoplastic Humans Leukemia, Myeloid, Acute - genetics MDS1 and EVI1 Complex Locus Protein Myelodysplastic Syndromes - genetics Promoter Regions, Genetic Proto-Oncogenes - genetics Transcription Factors - genetics Transcriptional Activation Translocation, Genetic
ISSN:	1097-4172, 1097-4172
Online Access:	Get more information
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