Tirofiban potentiates agonist-induced platelet activation and degranulation, despite effectively inhibiting aggregation

We aimed to investigate the effects of integrin αIIbβ3 inhibitor tirofiban on hallmarks of platelet activation, degranulation, and aggregation during its use to analyze activated but non-complexed platelets via flow cytometry. To do so, we used washed platelets from healthy human donors. We combined...

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Bibliographic Details

Published in:	Platelets (Edinburgh) Vol. 33; no. 8; pp. 1192 - 1198
Main Authors:	Aguiar Bucsai, Martina, Idel, Christian, Wollenberg, Barbara, Mannhalter, Christine, Verschoor, Admar
Format:	Journal Article
Language:	English
Published:	England Taylor & Francis 17.11.2022 Taylor & Francis Group
Subjects:	platelet activation platelet aggregation platelet degranulation platelet inhibition tirofiban platelet inhibition platelet degranulation tirofiban platelet activation platelet aggregation
ISSN:	0953-7104, 1369-1635, 1369-1635
Online Access:	Get full text
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