Cross-talk between IL-6 trans-signaling and AIM2 inflammasome/IL-1β axes bridge innate immunity and epithelial apoptosis to promote emphysema

Pulmonary emphysema is associated with dysregulated innate immune responses that promote chronic pulmonary inflammation and alveolar apoptosis, culminating in lung destruction. However, the molecular regulators of innate immunity that promote emphysema are ill-defined. Here, we investigated whether...

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Vydáno v:	Proceedings of the National Academy of Sciences - PNAS Ročník 119; číslo 36; s. e2201494119
Hlavní autoři:	Ruwanpura, Saleela M, McLeod, Louise, Dousha, Lovisa F, Seow, Huei J, West, Alison C, West, Alice J, Weng, Teresa, Alanazi, Mohammad, MacDonald, Martin, King, Paul T, Bardin, Philip G, Gabay, Cem, Klinman, Dennis M, Bozinovski, Steven, Vlahos, Ross, Anderson, Gary P, Rose-John, Stefan, Saad, Mohamed I, Jenkins, Brendan J
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 06.09.2022
Témata:	Animals Apoptosis Caspase 1 - metabolism Cytokine Receptor gp130 - metabolism DNA-Binding Proteins - genetics DNA-Binding Proteins - metabolism Humans Immunity, Innate Inflammasomes - metabolism Interleukin-1beta - genetics Interleukin-1beta - metabolism Interleukin-6 - genetics Interleukin-6 - metabolism Mice Pulmonary Emphysema - immunology apoptosis AIM2 inflammasome IL-6 emphysema
ISSN:	1091-6490, 1091-6490
On-line přístup:	Zjistit podrobnosti o přístupu
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