Idiosyncratic neural coding and neuromodulation of olfactory individuality in Drosophila

Innate behavioral biases and preferences can vary significantly among individuals of the same genotype. Though individuality is a fundamental property of behavior, it is not currently understood how individual differences in brain structure and physiology produce idiosyncratic behaviors. Here we pre...

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Veröffentlicht in:Proceedings of the National Academy of Sciences - PNAS Jg. 117; H. 38; S. 23292
Hauptverfasser: Honegger, Kyle S, Smith, Matthew A-Y, Churgin, Matthew A, Turner, Glenn C, de Bivort, Benjamin L
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 22.09.2020
Schlagworte:
Animals
Behavior, Animal
Brain - physiology
Calcium - metabolism
Drosophila - physiology
Female
Individuality
Neurons - physiology
Odorants - analysis
Smell
neuromodulation
neural encoding
individuality
sensory stimuli
odor preference
ISSN:1091-6490, 1091-6490
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Zusammenfassung:Innate behavioral biases and preferences can vary significantly among individuals of the same genotype. Though individuality is a fundamental property of behavior, it is not currently understood how individual differences in brain structure and physiology produce idiosyncratic behaviors. Here we present evidence for idiosyncrasy in olfactory behavior and neural responses in We show that individual female from a highly inbred laboratory strain exhibit idiosyncratic odor preferences that persist for days. We used in vivo calcium imaging of neural responses to compare projection neuron (second-order neurons that convey odor information from the sensory periphery to the central brain) responses to the same odors across animals. We found that, while odor responses appear grossly stereotyped, upon closer inspection, many individual differences are apparent across antennal lobe (AL) glomeruli (compact microcircuits corresponding to different odor channels). Moreover, we show that neuromodulation, environmental stress in the form of altered nutrition, and activity of certain AL local interneurons affect the magnitude of interfly behavioral variability. Taken together, this work demonstrates that individual exhibit idiosyncratic olfactory preferences and idiosyncratic neural responses to odors, and that behavioral idiosyncrasies are subject to neuromodulation and regulation by neurons in the AL.
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.1901623116