Asymmetry of parietal interhemispheric connections in humans

Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal trans...

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Veröffentlicht in:The Journal of neuroscience Jg. 31; H. 24; S. 8967
Hauptverfasser: Koch, Giacomo, Cercignani, Mara, Bonnì, Sonia, Giacobbe, Viola, Bucchi, Giulia, Versace, Viviana, Caltagirone, Carlo, Bozzali, Marco
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States 15.06.2011
Schlagworte:
Adult
Anisotropy
Brain Mapping
Corpus Callosum - physiology
Diffusion Magnetic Resonance Imaging
Electric Stimulation
Female
Functional Laterality - physiology
Humans
Image Processing, Computer-Assisted
Male
Neuronavigation - methods
Parietal Lobe - physiology
Psychomotor Performance - physiology
Space Perception - physiology
Time Factors
Transcranial Magnetic Stimulation - methods
Young Adult
ISSN:1529-2401, 1529-2401
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Abstract Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal transcranial magnetic stimulation, we show that the right, but not left, human posterior parietal cortex exerts a strong inhibitory activity over the contralateral homologous area by a short-latency connection. We also clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.
AbstractList Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal transcranial magnetic stimulation, we show that the right, but not left, human posterior parietal cortex exerts a strong inhibitory activity over the contralateral homologous area by a short-latency connection. We also clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal transcranial magnetic stimulation, we show that the right, but not left, human posterior parietal cortex exerts a strong inhibitory activity over the contralateral homologous area by a short-latency connection. We also clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.
Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced interaction between cerebral hemispheres, the underlying neurophysiological substrate is still largely unknown. Here, using a method of trifocal transcranial magnetic stimulation, we show that the right, but not left, human posterior parietal cortex exerts a strong inhibitory activity over the contralateral homologous area by a short-latency connection. We also clarify, using diffusion-tensor magnetic resonance imaging, that such an interaction is mediated by direct transcallosal projections located in the posterior corpus callosum. We argue that this anatomo-functional network may represent a possible neurophysiological basis for the ongoing functional asymmetry between parietal cortices, and that its damage could contribute to the clinical manifestations of neglect.
Author Cercignani, Mara
Bonnì, Sonia
Bucchi, Giulia
Koch, Giacomo
Giacobbe, Viola
Caltagirone, Carlo
Versace, Viviana
Bozzali, Marco
Author_xml – sequence: 1
  givenname: Giacomo
  surname: Koch
  fullname: Koch, Giacomo
  email: g.koch@hsantalucia.it
  organization: Laboratory of Clinical and Behavioural Neurology, Santa Lucia Foundation IRCCS, 00179 Rome, Italy. g.koch@hsantalucia.it
– sequence: 2
  givenname: Mara
  surname: Cercignani
  fullname: Cercignani, Mara
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  givenname: Viviana
  surname: Versace
  fullname: Versace, Viviana
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  givenname: Carlo
  surname: Caltagirone
  fullname: Caltagirone, Carlo
– sequence: 8
  givenname: Marco
  surname: Bozzali
  fullname: Bozzali, Marco
BackLink https://www.ncbi.nlm.nih.gov/pubmed/21677180$$D View this record in MEDLINE/PubMed
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Snippet Visuospatial abilities are preferentially mediated by the right hemisphere. Although this asymmetry of function is thought to be due to an unbalanced...
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SubjectTerms Adult
Anisotropy
Brain Mapping
Corpus Callosum - physiology
Diffusion Magnetic Resonance Imaging
Electric Stimulation
Female
Functional Laterality - physiology
Humans
Image Processing, Computer-Assisted
Male
Neuronavigation - methods
Parietal Lobe - physiology
Psychomotor Performance - physiology
Space Perception - physiology
Time Factors
Transcranial Magnetic Stimulation - methods
Young Adult
Title Asymmetry of parietal interhemispheric connections in humans
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