Immune activation of the host cell induces drug tolerance in Mycobacterium tuberculosis both in vitro and in vivo

Successful chemotherapy against Mycobacterium tuberculosis (Mtb) must eradicate the bacterium within the context of its host cell. However, our understanding of the impact of this environment on antimycobacterial drug action remains incomplete. Intriguingly, we find that Mtb in myeloid cells isolate...

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Bibliographic Details
Published in:	The Journal of experimental medicine Vol. 213; no. 5; p. 809
Main Authors:	Liu, Yancheng, Tan, Shumin, Huang, Lu, Abramovitch, Robert B, Rohde, Kyle H, Zimmerman, Matthew D, Chen, Chao, Dartois, Véronique, VanderVen, Brian C, Russell, David G
Format:	Journal Article
Language:	English
Published:	United States 02.05.2016
Subjects:	Animals Cell Line Drug Resistance, Bacterial - drug effects Drug Resistance, Bacterial - immunology Gene Expression Regulation, Bacterial - drug effects Gene Expression Regulation, Bacterial - immunology Isoniazid - pharmacology Lung - immunology Lung - microbiology Mice Mycobacterium tuberculosis - immunology Myeloid Cells - immunology Myeloid Cells - microbiology Rifampin - pharmacology Transcription, Genetic - drug effects Transcription, Genetic - immunology Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - immunology
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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