Vaccination against IL-31 for the treatment of atopic dermatitis in dogs
[...]the here-presented breakthrough therapy of vaccination against IL-31 is not only a promising mode to treat AD in dogs but may also facilitate the development of a similar vaccine in humans. Apoquel from Zoetis, the best current standard for the treatment of AD-induced pruritus in dogs, targets...
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| Vydané v: | Journal of allergy and clinical immunology Ročník 142; číslo 1; s. 279 - 281.e1 |
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| Hlavní autori: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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United States
Elsevier Inc
01.07.2018
Elsevier Limited |
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| ISSN: | 0091-6749, 1097-6825, 1097-6825 |
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| Abstract | [...]the here-presented breakthrough therapy of vaccination against IL-31 is not only a promising mode to treat AD in dogs but may also facilitate the development of a similar vaccine in humans. Apoquel from Zoetis, the best current standard for the treatment of AD-induced pruritus in dogs, targets Janus kinase 1, a downstream molecule of a number of cytokines including those pivotal for the allergic reaction, including IL-31.3 In animals and humans, IL-4 and IL-13 are known to be critical for the inflammatory process in AD, while IL-31 is pivotal for the itching.1 Furthermore, an mAb against IL-31 has recently been approved for the treatment of AD in dogs.4 Both Apoquel as well as the mAb against IL-31 have to be given relatively frequently (twice daily for Apoquel and monthly for the antibody). [...]vaccination against IL-31, which should induce a more sustained antibody response, may be a valuable addition or alternative to existing therapies. Dogs were immunized with 100 μg CMVTT formulated in alum on day 0. Because the vaccine was well tolerated and caused no itching, the dose was increased to 300 μg on weeks 3 and 6 (see Fig 1, B, for study outline). |
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| AbstractList | [...]the here-presented breakthrough therapy of vaccination against IL-31 is not only a promising mode to treat AD in dogs but may also facilitate the development of a similar vaccine in humans. Apoquel from Zoetis, the best current standard for the treatment of AD-induced pruritus in dogs, targets Janus kinase 1, a downstream molecule of a number of cytokines including those pivotal for the allergic reaction, including IL-31.3 In animals and humans, IL-4 and IL-13 are known to be critical for the inflammatory process in AD, while IL-31 is pivotal for the itching.1 Furthermore, an mAb against IL-31 has recently been approved for the treatment of AD in dogs.4 Both Apoquel as well as the mAb against IL-31 have to be given relatively frequently (twice daily for Apoquel and monthly for the antibody). [...]vaccination against IL-31, which should induce a more sustained antibody response, may be a valuable addition or alternative to existing therapies. Dogs were immunized with 100 μg CMVTT formulated in alum on day 0. Because the vaccine was well tolerated and caused no itching, the dose was increased to 300 μg on weeks 3 and 6 (see Fig 1, B, for study outline). |
| Author | Favrot, Claude Zeltins, Andris Tars, Kaspars Bachmann, Martin F. Kalnins, Gints Rostaher, Ana Balke, Ina Fischer, Nina |
| Author_xml | – sequence: 1 givenname: Martin F. surname: Bachmann fullname: Bachmann, Martin F. email: martin.bachmann@me.com organization: RIA Immunology, Inselspital, University of Bern, Bern, Switzerland – sequence: 2 givenname: Andris surname: Zeltins fullname: Zeltins, Andris organization: Latvian Biomedical Research & Study Centre, Riga, Latvia – sequence: 3 givenname: Gints surname: Kalnins fullname: Kalnins, Gints organization: Latvian Biomedical Research & Study Centre, Riga, Latvia – sequence: 4 givenname: Ina surname: Balke fullname: Balke, Ina organization: Latvian Biomedical Research & Study Centre, Riga, Latvia – sequence: 5 givenname: Nina surname: Fischer fullname: Fischer, Nina organization: Vetsuisse Faculty, Dermatology Unit, University of Zurich, Wonterthurerstrasse, Zurich, Switzerland – sequence: 6 givenname: Ana surname: Rostaher fullname: Rostaher, Ana organization: Vetsuisse Faculty, Dermatology Unit, University of Zurich, Wonterthurerstrasse, Zurich, Switzerland – sequence: 7 givenname: Kaspars surname: Tars fullname: Tars, Kaspars organization: Latvian Biomedical Research & Study Centre, Riga, Latvia – sequence: 8 givenname: Claude surname: Favrot fullname: Favrot, Claude organization: Vetsuisse Faculty, Dermatology Unit, University of Zurich, Wonterthurerstrasse, Zurich, Switzerland |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/29627081$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1111/vde.12088 10.1038/mt.2015.227 10.1111/all.13239 10.1038/nri2868 10.1016/S0165-2427(01)00296-3 |
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| References | Cavelti-Weder, Timper, Seelig, Keller, Osranek, Lässing (bib7) 2016; 24 Accessed 2016. Bachmann, Jennings (bib5) 2010; 10 Furue, Yamamura, Kido-Nakahara, Nakahara, Fukui (bib1) 2018; 73 Zoetis.com. Zoetis receives USDA license for CYTOPOINT. Available at Hillier, Griffin (bib2) 2001; 81 Cosgrove, Wren, Cleaver, Walsh, Follis, King (bib3) 2013; 24 Zeltins, West, ZabelF, Turabi, Balke, Haas (bib6) 2017; 2 Bachmann (10.1016/j.jaci.2017.12.994_bib5) 2010; 10 Hillier (10.1016/j.jaci.2017.12.994_bib2) 2001; 81 Cavelti-Weder (10.1016/j.jaci.2017.12.994_bib7) 2016; 24 Furue (10.1016/j.jaci.2017.12.994_bib1) 2018; 73 Cosgrove (10.1016/j.jaci.2017.12.994_bib3) 2013; 24 10.1016/j.jaci.2017.12.994_bib4 Zeltins (10.1016/j.jaci.2017.12.994_bib6) 2017; 2 |
| References_xml | – volume: 81 start-page: 147 year: 2001 end-page: 151 ident: bib2 article-title: The ACVD task force on canine atopic dermatitis (I): incidence and prevalence publication-title: Vet Immunol Immunopathol – volume: 2 start-page: 30 year: 2017 ident: bib6 article-title: A robust modular technology opening up the use of vaccine approaches to block signalling and treat chronic diseases even under limiting conditions publication-title: Nat PG Vaccines – reference: . Accessed 2016. – volume: 73 start-page: 29 year: 2018 end-page: 36 ident: bib1 article-title: Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis publication-title: Allergy – volume: 24 start-page: 587 year: 2013 end-page: 597 ident: bib3 article-title: A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel(R)) in client-owned dogs with atopic dermatitis publication-title: Vet Dermatol – volume: 24 start-page: 1003 year: 2016 end-page: 1012 ident: bib7 article-title: Development of an interleukin-1beta vaccine in patients with type 2 diabetes publication-title: Mol Ther – reference: Zoetis.com. Zoetis receives USDA license for CYTOPOINT. Available at: – volume: 10 start-page: 787 year: 2010 end-page: 796 ident: bib5 article-title: Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns publication-title: Nat Rev Immunol – volume: 24 start-page: 587 year: 2013 ident: 10.1016/j.jaci.2017.12.994_bib3 article-title: A blinded, randomized, placebo-controlled trial of the efficacy and safety of the Janus kinase inhibitor oclacitinib (Apoquel(R)) in client-owned dogs with atopic dermatitis publication-title: Vet Dermatol doi: 10.1111/vde.12088 – ident: 10.1016/j.jaci.2017.12.994_bib4 – volume: 24 start-page: 1003 year: 2016 ident: 10.1016/j.jaci.2017.12.994_bib7 article-title: Development of an interleukin-1beta vaccine in patients with type 2 diabetes publication-title: Mol Ther doi: 10.1038/mt.2015.227 – volume: 73 start-page: 29 year: 2018 ident: 10.1016/j.jaci.2017.12.994_bib1 article-title: Emerging role of interleukin-31 and interleukin-31 receptor in pruritus in atopic dermatitis publication-title: Allergy doi: 10.1111/all.13239 – volume: 10 start-page: 787 year: 2010 ident: 10.1016/j.jaci.2017.12.994_bib5 article-title: Vaccine delivery: a matter of size, geometry, kinetics and molecular patterns publication-title: Nat Rev Immunol doi: 10.1038/nri2868 – volume: 2 start-page: 30 year: 2017 ident: 10.1016/j.jaci.2017.12.994_bib6 article-title: A robust modular technology opening up the use of vaccine approaches to block signalling and treat chronic diseases even under limiting conditions publication-title: Nat PG Vaccines – volume: 81 start-page: 147 year: 2001 ident: 10.1016/j.jaci.2017.12.994_bib2 article-title: The ACVD task force on canine atopic dermatitis (I): incidence and prevalence publication-title: Vet Immunol Immunopathol doi: 10.1016/S0165-2427(01)00296-3 |
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| SubjectTerms | Antigens Atopic dermatitis Dermatitis Dogs Immunization Quality of life Skin diseases Vaccination Viruses |
| Title | Vaccination against IL-31 for the treatment of atopic dermatitis in dogs |
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