Adolescent development of multiscale structural wiring and functional interactions in the human connectome

Adolescence is a time of profound changes in the physical wiring and function of the brain. Here, we analyzed structural and functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y ( = 199). Core to our work was an advanced in vivo model of cortical wiring inco...

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Vydáno v:Proceedings of the National Academy of Sciences - PNAS Ročník 119; číslo 27; s. e2116673119
Hlavní autoři: Park, Bo-Yong, Paquola, Casey, Bethlehem, Richard A I, Benkarim, Oualid, Mišić, Bratislav, Smallwood, Jonathan, Bullmore, Edward T, Bernhardt, Boris C
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States 05.07.2022
Témata:
Adolescent
Adolescent Development
Brain - physiology
Brain - ultrastructure
Connectome
Cross-Sectional Studies
Humans
Magnetic Resonance Imaging
Nerve Net - physiology
Nerve Net - ultrastructure
brain development
cortical gradients
connectome
structure function
ISSN:1091-6490, 1091-6490
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Shrnutí:Adolescence is a time of profound changes in the physical wiring and function of the brain. Here, we analyzed structural and functional brain network development in an accelerated longitudinal cohort spanning 14 to 25 y ( = 199). Core to our work was an advanced in vivo model of cortical wiring incorporating MRI features of corticocortical proximity, microstructural similarity, and white matter tractography. Longitudinal analyses assessing age-related changes in cortical wiring identified a continued differentiation of multiple corticocortical structural networks in youth. We then assessed structure-function coupling using resting-state functional MRI measures in the same participants both via cross-sectional analysis at baseline and by studying longitudinal change between baseline and follow-up scans. At baseline, regions with more similar structural wiring were more likely to be functionally coupled. Moreover, correlating longitudinal structural wiring changes with longitudinal functional connectivity reconfigurations, we found that increased structural differentiation, particularly between sensory/unimodal and default mode networks, was reflected by reduced functional interactions. These findings provide insights into adolescent development of human brain structure and function, illustrating how structural wiring interacts with the maturation of macroscale functional hierarchies.
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ISSN:1091-6490
1091-6490
DOI:10.1073/pnas.2116673119