NLRX1 dampens oxidative stress and apoptosis in tissue injury via control of mitochondrial activity

Mitochondrial dysfunction is the most prominent source of oxidative stress in acute and chronic kidney disease. NLRX1 is a receptor of the innate immune system that is ubiquitously expressed and localized in mitochondria. We investigated whether NLRX1 may act at the interface of metabolism and innat...

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Vydané v:	The Journal of experimental medicine Ročník 214; číslo 8; s. 2405
Hlavní autori:	Stokman, Geurt, Kors, Lotte, Bakker, Pieter J, Rampanelli, Elena, Claessen, Nike, Teske, Gwendoline J D, Butter, Loes, van Andel, Harmen, van den Bergh Weerman, Marius A, Larsen, Per W B, Dessing, Mark C, Zuurbier, Coert J, Girardin, Stephen E, Florquin, Sandrine, Leemans, Jaklien C
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States 07.08.2017
Predmet:	Animals Apoptosis - physiology Disease Models, Animal Humans Ischemia - physiopathology Kidney - blood supply Kidney - metabolism Kidney - physiopathology Male Mice, Inbred C57BL Mitochondria - physiology Mitochondrial Proteins - physiology Oxidative Stress - physiology Reperfusion Injury - physiopathology
ISSN:	1540-9538, 1540-9538
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