Oxidative Stress in Preeclampsia and Placental Diseases

Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne...

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Bibliographic Details
Published in:International journal of molecular sciences Vol. 19; no. 5; p. 1496
Main Authors: Aouache, Rajaa, Biquard, Louise, Vaiman, Daniel, Miralles, Francisco
Format: Journal Article
Language:English
Published: Switzerland MDPI AG 17.05.2018
MDPI
Subjects:
Free radicals
Placenta
Preeclampsia
Review
placenta
vascular endothelium
preeclampsia
oxidative stress
pregnancy
ISSN:1422-0067, 1661-6596, 1422-0067
Online Access:Get full text
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Summary:Preeclampsia is a persistent hypertensive gestational disease characterized by high blood pressure and proteinuria, which presents from the second trimester of pregnancy. At the cellular level, preeclampsia has largely been associated with the release of free radicals by the placenta. Placenta-borne oxidative and nitrosative stresses are even sometimes considered as the major molecular determinants of the maternal disease. In this review, we present the recent literature evaluating free radical production in both normal and pathological placentas (including preeclampsia and other major pregnancy diseases), in humans and animal models. We then assess the putative effects of these free radicals on the placenta and maternal endothelium. This analysis was conducted with regard to recent papers and possible therapeutic avenues.
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These two authors contribute equally to this paper.
ISSN:1422-0067
1661-6596
1422-0067
DOI:10.3390/ijms19051496