Reduction of lamin B receptor levels by miR-340-5p disrupts chromatin, promotes cell senescence and enhances senolysis

Abstract A major stress response influenced by microRNAs (miRNAs) is senescence, a state of indefinite growth arrest triggered by sublethal cell damage. Here, through bioinformatic analysis and experimental validation, we identified miR-340-5p as a novel miRNA that foments cellular senescence. miR-3...

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Bibliographic Details

Published in:	Nucleic acids research Vol. 49; no. 13; pp. 7389 - 7405
Main Authors:	Herman, Allison B, Anerillas, Carlos, Harris, Sophia C, Munk, Rachel, Martindale, Jennifer L, Yang, Xiaoling, Mazan-Mamczarz, Krystyna, Zhang, Yongqing, Heckenbach, Indra J, Scheibye-Knudsen, Morten, De, Supriyo, Sen, Payel, Abdelmohsen, Kotb, Gorospe, Myriam
Format:	Journal Article
Language:	English
Published:	England Oxford University Press 21.07.2021
Subjects:	Cell Line Cell Proliferation Cells, Cultured Cellular Senescence - drug effects Cellular Senescence - genetics Gene Expression Regulation Gene regulation, Chromatin and Epigenetics Heterochromatin Humans Lamin B Receptor MicroRNAs - metabolism Receptors, Cytoplasmic and Nuclear - genetics Receptors, Cytoplasmic and Nuclear - metabolism
ISSN:	0305-1048, 1362-4962, 1362-4962
Online Access:	Get full text
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