Effects of SARS-CoV-2 on Cardiovascular System: The Dual Role of Angiotensin-Converting Enzyme 2 (ACE2) as the Virus Receptor and Homeostasis Regulator-Review

Angiotensin-converting enzyme 2 (ACE2) is the entry receptor for severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), the cause of Coronavirus Disease-2019 (COVID-19) in humans. ACE-2 is a type I transmembrane metallocarboxypeptidase expressed in vascular endothelial cells, alveolar type 2...

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Bibliographic Details
Published in:	International journal of molecular sciences Vol. 22; no. 9; p. 4526
Main Authors:	Aleksova, Aneta, Gagno, Giulia, Sinagra, Gianfranco, Beltrami, Antonio Paolo, Janjusevic, Milijana, Ippolito, Giuseppe, Zumla, Alimuddin, Fluca, Alessandra Lucia, Ferro, Federico
Format:	Journal Article
Language:	English
Published:	Switzerland MDPI AG 26.04.2021 MDPI
Subjects:	ADAM17 Protein - metabolism Angiotensin-Converting Enzyme 2 - metabolism Cardiovascular Diseases - complications Cardiovascular Diseases - pathology Coronaviruses COVID-19 - complications COVID-19 - pathology COVID-19 - prevention & control COVID-19 - virology COVID-19 vaccines COVID-19 Vaccines - immunology Hormones Humans Immune response Receptors, Virus - metabolism Review SARS-CoV-2 - isolation & purification SARS-CoV-2 - physiology Serine Endopeptidases - metabolism Viral infections COVID-19 ACE2 ADAM17 cardiovascular system RAS vaccines TMPRSS2 pandemic SARS- CoV-2
ISSN:	1422-0067, 1661-6596, 1422-0067
Online Access:	Get full text
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