TAK1 restricts spontaneous NLRP3 activation and cell death to control myeloid proliferation

The NOD-like receptor (NLR)-P3 inflammasome is a global sensor of infection and stress. Elevated NLRP3 activation levels are associated with human diseases, but the mechanisms controlling NLRP3 inflammasome activation are largely unknown. Here, we show that TGF-β activated kinase-1 (TAK1) is a centr...

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Bibliographic Details

Published in:	The Journal of experimental medicine Vol. 215; no. 4; p. 1023
Main Authors:	Malireddi, R K Subbarao, Gurung, Prajwal, Mavuluri, Jayadev, Dasari, Tejasvi Krishna, Klco, Jeffery M, Chi, Hongbo, Kanneganti, Thirumala-Devi
Format:	Journal Article
Language:	English
Published:	United States 02.04.2018
ISSN:	1540-9538, 1540-9538
Online Access:	Get more information
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